Podcasts > The School of Greatness > How to REVERSE Aging With What You Eat Daily

How to REVERSE Aging With What You Eat Daily

By Lewis Howes

In this episode of The School of Greatness, Dr. Michael Greger discusses how diet and lifestyle choices can influence the aging process. He explains that while genetics play a role in longevity, daily habits like maintaining a healthy weight, exercising, and eating specific foods can add up to a decade of life. The discussion covers how certain dietary choices activate anti-aging pathways in the body and potentially reverse aspects of aging.

Dr. Greger delves into practical dietary recommendations, including the benefits of whole-food plant-based nutrition, the importance of meal timing, and the role of fasting in cellular health. He also addresses gaps in medical education regarding nutrition and explains how the current healthcare system often overlooks evidence-based nutrition information due to profit-driven motivations.

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How to REVERSE Aging With What You Eat Daily

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How to REVERSE Aging With What You Eat Daily

1-Page Summary

The Science of Longevity and Anti-Aging

Dr. Michael Greger explains that while genetics accounts for only about 25% of lifespan differences, lifestyle choices can significantly impact longevity. He notes that basic behaviors like maintaining a healthy weight, exercising, and eating fruits and vegetables can add up to a decade of life. According to Greger, slowing the aging process through lifestyle interventions can reduce the risk of age-related diseases like stroke, dementia, and cancer. He discusses how the "anti-aging pathway," activated by vinegar, exercise, and calorie restriction, can potentially reverse aspects of aging.

Optimizing Diet and Nutrition For Health and Longevity

Greger emphasizes the importance of a whole-food, plant-based diet for longevity. He identifies legumes as particularly beneficial, noting they provide prebiotics that support gut health and improve immunity. Walnuts receive special attention, as Greger explains they contain more omega-3 fatty acids and antioxidants than other nuts, with studies showing they can improve artery function within hours of consumption. On sodium intake, Greger advocates for reducing processed foods and suggests switching to potassium salt (with medical approval) to effectively reduce cardiovascular disease risk.

Other Lifestyle Factors Beyond Diet That Impact Aging

The discussion turns to meal timing and fasting. Greger explains that while autophagy (cellular cleaning) requires 36-48 hours of fasting under medical supervision, benefits can be achieved through shorter fasting windows. He recommends limiting daily eating to a 12-hour window earlier in the day, noting that people in longevity hotspots typically eat light, early dinners. According to Greger, aligning meals with circadian rhythms enhances metabolic health and the body's ability to process nutrients.

Medical System Critiques and Change Recommendations

Greger highlights significant gaps in medical education regarding nutrition, revealing that even at top medical schools, doctors receive minimal training in clinical nutrition. He points out that this deficiency is particularly problematic given that 80% of primary care visits involve lifestyle-related chronic diseases. Through his work with the American College of Lifestyle Medicine and NutritionFacts.org, Greger aims to address this knowledge gap by disseminating evidence-based nutrition information that the current healthcare system often overlooks due to profit-driven motivations.

1-Page Summary

Additional Materials

Counterarguments

  • While genetics may account for about 25% of lifespan differences, this estimate can vary, and the influence of genetics might be more complex, with certain genetic factors having a larger impact on specific individuals or populations.
  • Adding a decade of life through lifestyle choices is a generalization and may not apply equally to everyone, as individual responses to lifestyle changes can vary significantly.
  • Lifestyle interventions can reduce the risk of age-related diseases, but they are not a guarantee, and some individuals may still develop these conditions despite a healthy lifestyle due to other risk factors.
  • The concept of an "anti-aging pathway" is an oversimplification, as aging is a complex process influenced by numerous biological pathways and environmental factors.
  • A whole-food, plant-based diet may not be optimal for everyone, as individual nutritional needs can vary based on factors like age, sex, health status, and activity level.
  • While legumes are generally healthy, some individuals may have difficulty digesting them or may have allergies or intolerances that make legumes an unsuitable dietary choice.
  • The benefits of walnuts and other specific foods may not be as significant when considering the overall dietary pattern and lifestyle of an individual.
  • Switching to potassium salt may not be suitable for everyone, especially those with kidney disease or other conditions that require potassium restriction.
  • The benefits of fasting and meal timing can vary, and some research suggests that the impact on longevity is not yet fully understood.
  • Recommendations for meal timing and fasting may not be practical or beneficial for all individuals, considering diverse lifestyles and cultural practices.
  • The critique of medical education may not fully acknowledge the efforts and improvements made in some medical schools to incorporate nutrition and lifestyle medicine into their curricula.
  • The assertion that the healthcare system often overlooks evidence-based nutrition information due to profit-driven motivations may not account for the complexity of healthcare delivery and the various factors that influence medical practice and education.
  • While organizations like the American College of Lifestyle Medicine and NutritionFacts.org provide valuable information, they represent specific viewpoints that may not encompass the full spectrum of nutritional science or medical opinion.

Actionables

  • You can track your eating habits with a photo food diary to align meals with circadian rhythms and monitor your intake of fruits, vegetables, and legumes. Instead of writing down everything you eat, take a quick photo before each meal or snack. This visual record can help you notice patterns, such as whether you're eating within a 12-hour window or if you're incorporating enough whole foods into your diet. It's a simple way to stay accountable and make gradual improvements to your eating habits.
  • Create a "kitchen shutdown" ritual to encourage early, lighter dinners, mimicking the habits of longevity hotspots. Set a specific time each evening when the kitchen is "closed" for food preparation and snacking, ideally a few hours before bedtime. This could involve a physical act like cleaning and turning off the lights or a symbolic one like placing a sign or cloth over the kitchen counter. This habit can help you avoid late-night eating, which aligns with the practice of eating light, early dinners for better metabolic health.
  • Engage in a monthly "pantry purge" to reduce processed foods and increase your intake of beneficial nutrients like omega-3 fatty acids and antioxidants. Once a month, go through your pantry and remove items that are highly processed or contain unhealthy additives. Replace them with healthier alternatives, such as swapping out regular snack nuts for walnuts or choosing whole grain options over refined ones. This regular activity not only improves the quality of your food supply but also reinforces your commitment to a whole-food, plant-based diet.

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How to REVERSE Aging With What You Eat Daily

The Science of Longevity and Anti-Aging

Dr. Michael Greger provides insight into how a healthy diet, lifestyle changes, and understanding of cellular processes can contribute to longevity and potentially slow down the aging process.

Slowing Aging Lowers Risk of Many Fatal Diseases

Most Premature Deaths and Disabilities Are Preventable Through Diet and Lifestyle, Not Genetics

Greger emphasizes that the vast majority of premature deaths and disabilities are preventable, with only about 25% of the differences in lifespan between people due to genetics. This highlights the significant impact of lifestyle on longevity. He argues that basic behaviors, including not smoking, maintaining a healthy weight, exercising, and consuming fruits and vegetables, can add up to a decade of life. Greger also discusses cellular senescence, one of the aging pathways he covers in his book, suggesting that lifestyle interventions can influence this process.

Premature Aging Exponentially Raises Heart Attack, Stroke, and Cancer Risk

According to Greger, slowing down the aging process can reduce the risk of various diseases, which rise exponentially with age. He specifically mentions stroke, dementia, cancer, and heart disease. Premature senescence of cells, which can be prevented by consuming antioxidant-rich foods like berries and greens, relates directly to the prevention of these diseases through diet and lifestyle, rather than genetics alone.

Reversing Aging Can Extend Lifespan and Enhance Quality of Life

Greger introduces the "anti-aging pathway," which can be activated by acetic acid found in vinegar and is further stimulated by exercise and calorie restriction. This pathway has the potential to reverse aspects of aging, thus enhancing both lifespan and quality of life. Greger also highlights the Ha ...

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The Science of Longevity and Anti-Aging

Additional Materials

Clarifications

  • Cellular senescence is when cells permanently stop dividing in response to stress or damage, preventing potential cancer growth. It is triggered by factors like DNA damage and telomere shortening, which act as a biological clock limiting cell replication. While senescence protects against tumors, the accumulation of these non-dividing cells contributes to aging and related diseases by promoting inflammation. Clearing senescent cells can improve tissue function and reduce age-related decline.
  • The "anti-aging pathway" refers to biological mechanisms that slow or reverse cellular aging. One key pathway involves activating sirtuins, proteins that regulate cellular health and longevity. Acetic acid, exercise, and calorie restriction can stimulate these pathways, enhancing cell repair and metabolism. This activation helps reduce damage accumulation, promoting healthier aging.
  • Acetic acid is the main component of vinegar and can activate certain cellular pathways linked to longevity, such as AMPK, which helps regulate energy balance. This activation mimics some effects of calorie restriction, a known method to extend lifespan in various organisms. By promoting these pathways, acetic acid may enhance cellular repair and reduce inflammation. Its role in anti-aging is still being researched but shows promise in supporting metabolic health and longevity.
  • The Hayflick limit is the maximum number of times a normal human cell can divide before it stops, entering a state called senescence. This limit acts as a natural barrier to uncontrolled cell growth, helping prevent cancer. It reflects cellular aging, linking the lifespan of cells to the aging of the whole organism. Understanding this limit helps explain why cells eventually lose the ability to regenerate, impacting overall aging.
  • Senescent cells are damaged or aged cells that no longer divide but do not die off as they should. They release harmful substances called pro-inflammatory cytokines, which cause chronic inflammation in tissues. This inflammation contributes to tissue dysfunction and accelerates aging-related diseases. Clearing these cells can reduce inflammation and improve health during aging.
  • Senolytic compounds are substances that target and eliminate senescent cells, which are damaged cells that no longer divide and contribute to aging and inflammation. By removing these cells, senolytics may reduce age-related diseases and improve overall health. These compounds are being studied for their potential to extend lifespan and enhance immune function. Some senolytics are derived from cancer drugs and are currently in early research or clinical trials.
  • Calorie restriction means reducing daily calorie intake without malnutrition. It has been shown in many animal studies to slow aging and extend lifespan by improving cellular repair and reducing metabolic stress. This process activates certain genes and pathways that enhance cell maintenance and reduce inflammation. In humans, moderate calorie restriction may improve health markers linked to aging, tho ...

Counterarguments

  • Genetics may play a more significant role in longevity and disease predisposition than the text suggests, as some individuals with healthy lifestyles still develop diseases early or do not live long lives due to their genetic makeup.
  • The impact of social determinants of health, such as socioeconomic status, education, and access to healthcare, on longevity and aging is not addressed, which can be as significant as individual lifestyle choices.
  • The idea that aging can be significantly reversed through lifestyle interventions and specific compounds is still a matter of scientific debate, with some researchers arguing that the aging process is more complex and less easily influenced.
  • The effectiveness of senolytic compounds in extending lifespan and reversing aging in humans has not been conclusively proven, as most research has been conducted in animal models or in vitro.
  • The claim that adopting a healthier lifestyle can reduce all-cause mortality risk by 40% may not account for other confounding factors and may not be replicable across all populations.
  • The concept of the Hayflick limit as a protective process against cancer is an oversimplification, as cancer is a multifactorial disease and other mechanisms, such as DNA repair and tumor suppressor genes, also play critical roles.
  • The assertion that lifestyle changes can add up to a decade of life is difficult to ...

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How to REVERSE Aging With What You Eat Daily

Optimizing Diet and Nutrition For Health and Longevity

Whole-Food, Plant-Based Diet Focused On Legumes, Nuts, Veggies, and Fruits Keys Longevity

Michael Greger emphasizes the importance of a whole-food, plant-based diet for health and longevity, supported by research pointing to blue zones, where people live longer and healthier lives.

Legumes: A Longevity-Boosting Prebiotic Source For Microbiome

Legumes, such as beans, split peas, chickpeas, and lentils, are noted by Greger to be associated with the largest expected life expectancy gains according to a study. He suggests including more legumes in your diet because they are the most concentrated sources of prebiotics, such as resistant starch and dietary fiber, that feed the good bacteria in our gut. Legumes are also linked to benefits like decreased inflammation, improved immunity, and muscle strength in frail individuals.

Walnuts Boost Heart Health and Longevity

Greger asserts that nuts, especially walnuts, are associated with the longest lifespan. Walnuts contain more omega-3 fatty acids and antioxidants than other nuts and are the only nuts that have been shown to improve artery function within hours of consumption. They also played a critical role in the PRET-D-Med study in reducing cardiovascular disease rates. Consuming a palmful of walnuts daily is recommended, with health benefits plateauing at one ounce, potentially adding up to two years to lifespan.

Michael Greger discusses the benefits of eating walnuts, including their impact on heart health. Interventional trials showed that walnuts might improve heart health and cholesterol levels. This could be a contributing factor to their ability to prolong life, as demonstrated by observational studies that found decreased heart disease risk among nut eaters.

Greger advocates for the consumption of unsalted nuts and a reduction in sodium intake, as it's the number one dietary risk factor for death globally. Most of the sodium in our diet comes from processed foods. Greger expl ...

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Optimizing Diet and Nutrition For Health and Longevity

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Counterarguments

  • While a whole-food, plant-based diet can be beneficial, it may not be suitable for everyone due to individual nutritional needs, preferences, and cultural dietary patterns.
  • Some research suggests that certain populations may require more protein or specific nutrients that are more readily available in animal products, such as vitamin B12, iron, zinc, and omega-3 fatty acids.
  • The health benefits of legumes are well-documented, but some individuals may have difficulty digesting them or may suffer from gastrointestinal discomfort due to their high fiber content.
  • The claim that walnuts can add up to two years to lifespan is based on observational studies, which can show associations but do not prove causation.
  • While walnuts are nutritious, they are also high in calories, which could contribute to weight gain if consumed in large quantities without considering overall calorie intake.
  • The recommendation to switch from sodium salt to potassium salt may not be appropriate for everyone, especially those with conditions affecting potassium levels, such as kidney disease or those on certain medications.
  • The advice to keep salt intake under 1500 milligrams may be too restrictive for some individuals, particularly athletes ...

Actionables

- You can create a "Legume of the Week" challenge where each week you incorporate a different type of legume into your meals, experimenting with recipes like lentil soups, chickpea salads, or black bean tacos to diversify your diet and boost your intake of prebiotics.

  • By focusing on one legume per week, you'll learn how to prepare it in various ways, ensuring you don't get bored and making it more likely you'll continue to include these healthy foods in your diet. For example, you might make Monday your lentil day, trying out a new lentil curry or stew each week.
  • Start a "Walnut Wednesday" tradition where you add a palmful of walnuts to your meals or snacks on Wednesdays, ensuring you get a weekly dose of omega-3 fatty acids and antioxidants.
  • This could mean adding walnuts to your morning oatmeal, blending them into a smoothie, or tossing them over a salad at lunch. By setting a specific day, you create a routine that makes it easier to remember and stick to, and it can be a fun way to involve family or friends in your health journey.
  • Develop a habit of reading nutrition labels to identify and reduce high-s ...

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How to REVERSE Aging With What You Eat Daily

Other Lifestyle Factors Beyond Diet That Impact Aging

Michael Greger and Lewis Howes discuss how factors beyond what you eat can impact aging, focusing on meal timing and its relation to the body's natural processes.

Skipping Dinner Boosts Anti-Aging Pathways

The conversation explores the benefits of narrowing the eating window and timing meals to align with the body's circadian rhythms.

Fasting Induces Autophagy, a Cellular Cleaning Process, but Requires Cautious Supervision

Greger explains that while autophagy, a cellular cleaning process, has benefits and contributes to the aging process, it generally doesn't ramp up until 36 to 48 hours into fasting. He stresses that prolonged fasting should be done under medical supervision to avoid serious health risks such as electrolyte abnormalities.

The discussion looks at the intermittent fasting literature, which Greger admits can be confusing. He highlights that fasting with an eating window earlier in the day has remarkable benefits, but when the eating window is late in the day, it could be harmful, potentially causing metabolic issues. Greger emphasizes skipping supper rather than breakfast and suggests that eating the same food in the morning rather than the evening leads to less of a blood sugar spike, due to the circadian rhythms.

Aligning Meal Timing With Circadian Rhythms Enhances Metabolic Health

Greger suggests that one should ideally collapse their daily feeding window to 12 hours or less, stressing that this eating schedule should be earlier in the day to align with circadian rhythms. He mentions that people in regions known for longevity tend not to eat a lot of dinners, or if they do, their dinners are light or early, typically before 7 PM or even before 4 PM.

He also highlights the importance of chronobiology and how our circadian rhythms have a significant impact on our biol ...

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Other Lifestyle Factors Beyond Diet That Impact Aging

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Counterarguments

  • While narrowing the eating window may have benefits, individual variability in metabolism and lifestyle may mean that this approach is not optimal for everyone.
  • The activation of autophagy after 36 to 48 hours of fasting is a general statement and may vary significantly between individuals based on their unique biology and health status.
  • Prolonged fasting, even with medical supervision, may not be suitable for everyone, especially those with certain medical conditions, the elderly, or those with a history of eating disorders.
  • The benefits of intermittent fasting and early time-restricted feeding are supported by some research, but other studies suggest that the benefits may not be as significant as claimed or may not apply to all populations.
  • The assertion that eating late in the day causes metabolic issues may not account for cultural, social, and individual differences in eating patterns and their effects on health.
  • The recommendation to skip dinner could conflict with social and family dynamics, where dinner is a primary meal for family gathering and social interaction.
  • The idea that eating the same food in the morning causes less of a blood sugar spike than in the evening is an oversimplification and may not consider other factors that affect glycemic response, such as food composition, individual insulin sensitivity, and physical activity levels.
  • The suggestion to collapse the daily feeding window to 12 hours or less may not take into account the needs of athletes or those with higher energy expenditures who may require a more extended feeding window to meet their nutritional and energy needs.
  • The link between longevity and early or light dinners in certain populations may be c ...

Actionables

  • You can use a meal timing journal to track your eating patterns and adjust them for earlier windows, noting how you feel and your energy levels throughout the day. Start by recording the times you eat each meal and snack for a week. Then, gradually shift your eating times earlier each day, aiming to finish your last meal by 7 PM. Observe changes in your sleep quality, alertness, and hunger levels to fine-tune your eating schedule.
  • Create a "kitchen curfew" by setting a nightly alarm an hour before your intended dinner time to remind you to start preparing your meal. This helps establish a routine where you consistently eat dinner earlier. For example, if you decide that 6 PM is your target dinner time, set an alarm for 5 PM as a cue to begin meal prep, ensuring you have ample time to eat without rushing before your curfew.
  • Experiment with a "breakfast chal ...

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How to REVERSE Aging With What You Eat Daily

Medical System Critiques and Change Recommendations

Michael Greger outlines serious deficiencies in the medical system's approach to chronic disease prevention and treatment, highlighting a need for greater focus on nutrition education within the medical field and confronting the consequences of profit-driven health care.

Medical Field Lacks Focus On Nutrition and Lifestyle for Chronic Disease Prevention and Treatment

Doctors Lack Nutrition Education, Ill-equipped For Addressing Illness Roots

Lewis Howes brings up that medical education largely neglects nutrition, often offering at most an hour-long class on the subject. Greger agrees, pointing out that even in medical schools known for their nutrition training, such as the one he attended, he received only 19 hours of instruction, much of which focused on basic biochemistry rather than clinical nutrition or using diet to prevent or reverse diseases. Greger states that graduating doctors, as a result, lack the tools to fully heal patients despite lifestyle-related chronic diseases making up 80% of primary care visits.

Profit Motives Favor Symptom Treatment Over Disease Prevention

Greger comments on how hospitals and the pharmaceutical industry profit from treatments and lifestyle drugs for chronic conditions, suggesting a financial incentive to treat symptoms rather than prevent disease through lifestyle changes. He also discusses how businesses maximize profit at the expense of public health, noting that unhealthy, processed foods offer higher profits due to lower production costs and longer shelf lives.

Challenge: Lack of Incentive In Spreading Evidence-Based Nutrition

Greger emphasizes that peer-reviewed medical literature establishes the foundations of what we know in medicine, but this knowledge has not been assimilated into clinical practice or public awareness due to a lack of direct profit motives. He also points out that beneficial studies on natural foods are not widely promoted because there isn't a lot of money to be made, and the profitability of foods is inversely related to their health benefits.

Greger highlights the absence of advertisements and promotional campaigns for healthy foods, due to their lack of brand identity, which precludes individual growers from profiting sufficiently to justify significant advertising ...

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Medical System Critiques and Change Recommendations

Additional Materials

Clarifications

  • "Group 1 carcinogen" is a classification by the International Agency for Research on Cancer (IARC) indicating that there is sufficient evidence that the substance causes cancer in humans. This is the highest level of certainty in cancer risk classification. Processed meats, like sausages and bacon, are in this group, meaning they have been scientifically linked to causing cancer. This classification urges public health actions to reduce exposure to these substances.
  • Lifestyle drugs are medications used to enhance quality of life rather than to treat serious illnesses. They often address conditions like weight loss, sexual performance, or hair growth. Unlike essential drugs for acute or life-threatening diseases, lifestyle drugs target non-critical, often cosmetic or convenience-related issues. Their widespread use can generate significant profits for pharmaceutical companies.
  • Peer-reviewed medical literature consists of research studies evaluated by experts before publication to ensure accuracy and validity. It serves as the primary source of new medical knowledge and evidence for healthcare professionals. Clinical practice guidelines and treatment protocols are often based on this literature to ensure care is effective and up-to-date. However, translating research findings into everyday medical practice can be slow and influenced by factors beyond scientific evidence.
  • Processed foods are more profitable because they often use cheap, long-lasting ingredients that reduce production and storage costs. They can be mass-produced and heavily marketed under recognizable brands, increasing sales volume. In contrast, fresh healthy foods spoil quickly and lack strong brand identity, limiting large-scale advertising and premium pricing. Additionally, processed foods frequently contain additives that enhance flavor and shelf life, encouraging repeat purchases.
  • The American College of Lifestyle Medicine is a professional organization that educates healthcare providers on using lifestyle changes, like diet and exercise, to prevent and treat chronic diseases. NutritionFacts.org is a nonprofit website that provides free, evidence-based nutrition information to the public. Both aim to fill gaps left by traditional medical education and promote healthier living through accessible knowledge. They work to shift healthcare focus from treating symptoms to preventing disease.
  • The comparison refers to how tobacco was once widely used and accepted despite clear evidence of its health risks. Over time, scientific research revealed tobacco's dangers, leading to public health campaigns and regulations that reduced its use. Similarly, current diets high in processed foods and unhealthy ingredients are linked to chronic diseases but lack strong public health action. Greger suggests that, like tobacco, harmful dietary patterns need more awareness and policy change to protect public health.
  • Chronic diseases like heart disease, diabetes, and obesity are largely caused by lifestyle factors such as poor diet, physical inactivity, smoking, and excessive alcohol use. These conditions are the leading reasons people visit primary care doctors, making up about 80% of such visits. Managing these diseases often requires long-term lifestyle changes rather than just medication. Preventing and treating them effectively can reduce healthcare costs and improve quality of life.
  • Medical schools prioritize acute care and pharmacology over nutrition because these areas align more directly with traditional medical treatments and emer ...

Counterarguments

  • Medical education is continuously evolving, and some medical schools are increasing their focus on nutrition and lifestyle medicine, recognizing their importance in chronic disease prevention and treatment.
  • The complexity of chronic diseases means that they often require multifaceted treatment approaches, including medication and medical interventions, in addition to lifestyle changes.
  • The pharmaceutical industry and hospitals provide essential services and medications that save lives and improve the quality of life for patients with chronic diseases, not just treating symptoms.
  • Processed foods are not inherently unhealthy, and there are many fortified and convenience foods that contribute to nutritional needs, especially in populations with limited access to fresh foods.
  • There are economic and logistical challenges associated with promoting and distributing fresh, unprocessed foods that go beyond simple profit motives, such as spoilage, transportation, and storage.
  • Many healthcare providers, including doctors, dietitians, and nurses, are committed to integrating evidence-based nutrition advice into their practice and actively promote lifestyle changes for disease prevention and management.
  • Governmental and non-profit organizations do promote healthy eating and lifestyle changes through various campaigns and initiatives, even if these efforts are not as visible or aggressive as commercial advertising.
  • The classification of processed meat as a Group 1 carcinogen by the International Agency for Research on Cancer (IARC ...

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