In this episode of On Purpose with Jay Shetty, Dr. Sara Szal explores the complex relationship between hormones and overall health. She explains how these chemical messengers work in the body and discusses common conditions that arise when hormonal balance is disrupted, including PCOS, endometriosis, and low testosterone.
The discussion covers several key aspects of hormonal health management, from the effects of chronic stress and insulin resistance to practical lifestyle changes that can help maintain balance. Szal shares insights about hormone testing, nutritional approaches, and stress management techniques. The conversation also addresses birth control considerations, examining both the long-term effects of hormonal contraceptives and natural alternatives for those seeking different options.

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Hormones serve as chemical messengers in the body, working alongside other components like peptides, proteins, and nutrients to maintain bodily functions and homeostasis. When this delicate balance is disrupted, various health issues can arise, including conditions like PCOS, endometriosis, and low [restricted term].
Sara Szal and Jay Shetty discuss how stress plays a central role in hormonal disruption. Szal explains that chronic stress can lead to elevated cortisol levels, which can deplete [restricted term] production and create a cascade of health issues. Additionally, [restricted term] resistance emerges as another significant factor, affecting metabolism, weight management, and reproductive health. Sex hormone imbalances can result in various symptoms, from fatigue and mood changes to infertility and metabolic issues.
Szal emphasizes that lifestyle and dietary changes can significantly impact hormonal balance. She recommends reducing carbohydrate intake and incorporating post-meal walks to improve [restricted term] sensitivity. For stress management, she advocates for meditation and breath work instead of harmful coping mechanisms like alcohol. Nutritional supplements, including omega-3s and CoQ10, can also support hormonal health. Szal strongly advocates for comprehensive hormone testing to achieve optimal, individualized levels rather than settling for "normal" ranges.
According to Szal, birth control pills can have significant long-term consequences, including reduced sex hormone-binding globulin, increased inflammation, and nutrient depletion. She recommends natural alternatives such as fertility tracking and copper IUDs. For those transitioning off birth control, Szal suggests a stepwise approach that includes assessing micronutrient deficiencies, monitoring hormone levels, and working with knowledgeable healthcare providers to ensure a smooth transition.
1-Page Summary
Hormones are described as one of the means through which the body maintains complex internal communication, governing a myriad of biological processes.
Hormones act as chemical messengers in the body, instructing various parts to perform specific actions. These messages are part of the body’s communication network, which also includes peptides, proteins, the genome, and nutrients—each playing a role in maintaining the body’s functions. Nutrients, in particular, are highlighted as a key driver of hormonal balance.
A hormonal imbalance disrupts homeostasis—the body's equilibrium—and can lead to several health issues.
Conditions such as polycystic ovary syndrome (PCOS) involve an excess of androgens or [restricted term], which can lead to infertility, acne, and other symptoms. Endometriosis, another condition affected by hormonal ilmbalances, can cause significant disco ...
Understanding Hormones and Hormonal Imbalances
Sara Szal and Jay Shetty delve into the world of hormonal imbalances, discussing their causes, particularly stress, and their impact on health such as metabolism, sexual health, and overall well-being.
Szal points out stress as a significant driver of hormonal imbalances, with cortisol levels being an indicator of one's stress response. Szal, who found her own cortisol levels substantially elevated due to chronic stress, warns that both high and low cortisol can signal issues with the stress response system.
High stress means a heightened stress response and a potential depletion of [restricted term] production in women as cortisol dominates. Szal discusses eustress or hormesis, which is a healthy form of stress, but excess stress can lead to cortisol taking over, resulting in disrupted relationships and wear and tear on the body. Chronic stress can acclimate the body to high cortisol levels, with family stress being one of the greatest causes.
Szal explains that [restricted term] resistance is when cells become desensitized to [restricted term], leading to elevated [restricted term] levels, increased fat storage, and higher blood sugar. Fortunately, [restricted term] sensitivity can be improved with dietary changes and exercise in a short period. She highlights the interplay of [restricted term] with metabolism and weight management, pointing out that [restricted term] dysregulation can affect ovarian function and is linked with conditions like polycystic ovary syndrome (PCOS).
[restricted term] resistance means that glucose struggles to enter cells, which can lead to elevated blood sugar levels. Monitoring glucose can detect this condition, and lifestyle interventions can quickly modify [restricted term] levels.
Imbalances in sex hormones lead to several health challenges, from infertility and acne to more severe conditions requiring medical attention.
Szal men ...
Causes and Impacts of Specific Hormonal Imbalances
Sara Szal and Jay Shetty dive into various approaches that can help address and balance hormones, focusing on lifestyle changes, stress management, and the importance of precise hormone testing.
Changing lifestyle and diet is a cornerstone in rebalancing [restricted term] and cortisol levels, which can quickly rectify hormonal issues like acne or irregular periods.
Szal states that by reducing carbohydrates in the diet, one can see a change in [restricted term] levels within a week, linking carb reduction to hormonal balance. She adds that a 10-minute walk after meals can significantly improve [restricted term] sensitivity and help with glucose management.
Szal also notes managing stress is vital for hormonal balance. Meditation and breath work are mentioned as practical tools in managing cortisol levels. Szal highlights the impact of stress perception on hormonal responses, suggesting that shifting perception can transform distress into eustress. She shares personal experiences to underline ineffective stress management strategies, such as using alcohol, and endorses meditation and other relaxing activities as better alternatives. Additionally, Szal emphasizes the importance of understanding one's stress response, especially in contexts like conception, because of cortisol’s significant influence on hormone hierarchy.
Nutritional supplements can counter nutrient depletion from hormonal imbalances.
Szal mentions the intake of omega-3s, at a dose of a thousand to 2000 milligrams, might aid with painful periods, while CoQ10 supports the mitochondria. She further notes that phosphatidylserine, at a dose of 400 milligrams, has the potential to reduce cortisol levels.
Szal strikes against the advice that hormone testing is futile due to fluctuations, asserting that it is worthwhile for capturing a more nuanced view of one's health.
Testing is critical not just to identify imbalances but to achieve optimal ranges tailored to individual needs. Szal argues for the relevance of hormo ...
Approaches To Addressing and Balancing Hormones
Sara Szal raises concerns about the widespread use of birth control pills, citing their role as hormone disruptors and the existence of preferable alternatives that utilize lifestyle changes.
Szal discusses the long-term consequences of taking birth control pills, emphasizing the lack of informed consent given to women and girls prescribed them.
Birth control pills reduce sex hormone-binding globulin (SHBG), which can decrease free [restricted term], leading to decreased libido or vaginal dryness in about 25% of women. Even after discontinuing use, SHBG can remain elevated, potentially impacting hormones long-term. Birth control use can also lead to elevated inflammation markers like high sensitivity C-reactive protein (HSCRP) and cause depletion in critical nutrients like magnesium, CoQ10, and B vitamins, impacting mitochondrial function.
Szal recommends that women affected by birth control side effects measure their inflammation and SHBG levels. She suggests beginning with an anti-inflammatory diet and a multivitamin to address the nutrient depletions caused by birth control pills.
Szal encourages natural contraception methods by monitoring the menstrual cycle, tracking temperature, and using wearables to identify fertility windows. She suggests considering lifestyle changes, such as increasing omega-3s through eating fish like salmon, to manage issues like painful periods that birth control pills are often prescribed to treat.
Szal also advocates for the copper IUD as a natural contraception option. She notes its high satisfaction rates among users due to its non-hormonal nature, and not requiring daily attention.
Szal provides a roadmap for women w ...
Concerns Around Birth Control Pills and Natural Alternatives
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