In this episode of Stuff You Should Know, the hosts examine Howard Hughes's four-year stay at Las Vegas's Desert Inn beginning in 1966, a period that illustrates both his severe mental decline and his paradoxical impact on the city. By age 59, Hughes had become a recluse suffering from opioid addiction, extreme OCD, and physical deterioration, occupying an entire hotel floor in isolation while subsisting on minimal food and refusing housekeeping for years.
Despite his compromised mental state, Hughes reshaped Las Vegas through strategic casino acquisitions, purchasing six major properties and transforming the city's image from mob-controlled gambling hub to legitimate corporate destination. The episode explores the network of associates who managed his business affairs without face-to-face contact, his troubling discriminatory views and policy proposals, and his ultimate deterioration until his death in 1976. The discussion reveals how immense wealth and isolation enabled Hughes's compulsions while simultaneously allowing him to leave a lasting mark on Las Vegas's development.

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Howard Hughes's later years were marked by severe mental illness and reclusiveness, with his 1966 stay at Las Vegas's Desert Inn offering a stark illustration of his deterioration. By then, Hughes had been unseen publicly since 1961 and arrived at the hotel at age 59, already compromised by opioid addiction from chronic pain following a plane crash. He had lost dozens of pounds and four inches of height due to physical neglect.
Hughes occupied the entire ninth floor of the Desert Inn, sealing all windows with curtains that eventually rotted in place. He refused housekeeping for four years, subsisting on candy bars, canned fruit, and milk, which left him malnourished and anemic. His severe OCD manifested in asymmetrical contamination fears—he was terrified of others' germs but indifferent to his own filth, rarely bathing and letting his hair and fingernails grow unchecked. Staff had to wear gloves when preparing documents for him, and Hughes famously wore tissue boxes as slippers and saved his urine in bottles, viewing them as extensions of himself.
Hughes's deterioration stemmed from multiple intersecting factors: opioid addiction from his plane crash injuries, unchecked mental health issues enabled by immense wealth and isolation, and childhood trauma from his hypochondriac mother who instilled deep germophobic tendencies in him from an early age.
Despite his declining mental health, Hughes fundamentally reshaped Las Vegas through strategic acquisitions that transformed the city from a mob-controlled gambling den to a respectable corporate destination.
Hughes arrived at the Desert Inn in 1966 seeking a tax shelter after selling his TWA stock. When the hotel needed his floor for New Year's Eve guests and asked him to leave, Hughes simply bought the property for $13.25 million rather than relocate. This unexpected purchase launched his casino empire. Between 1966 and 1968, Hughes acquired six major casino-hotels through his Summa Holding Corporation—the Desert Inn, Sands, Castaways, Silver Slipper, Landmark, and Frontier—nearly all from mob-connected sellers. A federal antitrust lawsuit stopped him from purchasing a seventh, preventing a monopoly.
Hughes envisioned transforming Las Vegas into a legitimate, family-friendly corporate destination—a smog-free, environmentally conscious city with efficient governance, free from crime and corruption. His involvement dramatically altered the city's public image, attracting business interest from figures like Kirk Kerkorian and spurring the Nevada Corporate Gaming Act, which eliminated background checks on every shareholder. This legal shift opened Las Vegas to public corporations and laid the foundation for the corporate-driven city it became.
Hughes relied on a complex network of trusted associates to manage his business while maintaining extreme isolation. Robert Mayhew served as his chief representative for eight to fifteen years without ever meeting Hughes face-to-face, communicating only through phone calls, memos, and conversations through doors. Mayhew made major decisions, negotiated with officials, and committed to enormous purchases based solely on these remote instructions.
The "Mormon Mafia"—six men, five of them Mormon—chosen for their trustworthiness and religious prohibitions against drinking, smoking, and gambling, served as Hughes's only personal contacts. They conveyed communications, provided [restricted term] injections, and catered to his obsessive cleanliness rituals using tissues. With his immense wealth enabling increasingly elaborate demands, Hughes once special-ordered 200 gallons of discontinued Baskin-Robbins banana ripple ice cream, only to lose interest, and issued twelve-step instructions for opening and serving canned peaches. This closed system allowed no external reality to challenge his compulsions.
Hughes's later years revealed troubling ideological positions and quixotic political proposals. In 1968, he attempted to cancel the Desert Inn's tennis tournament after learning Arthur Ashe would compete, fearing damage from Black spectators. Mayhew resisted, and Ashe went on to win the singles title in a symbolic victory over Hughes's discriminatory intentions.
Hughes proposed various policy changes: repealing sales, gas, and cigarette taxes while supporting segregated Clark County schools, banning talent from communist countries, and prohibiting rock festivals. He demanded personal exemptions from court appearances and insisted Las Vegas consult him before realigning any street. While Hughes gained gaming licenses without appearing before the Nevada Gaming Commission, authorities rejected most of his proposals as impractical. His suggestion to replace Lake Mead as Las Vegas's water source was firmly dismissed, highlighting the limits of even a billionaire's power over essential infrastructure.
On Thanksgiving Eve 1970, exactly four years after arriving, Hughes left Las Vegas on a stretcher via fire escape, relocating to the Bahamas where he repeated his reclusive pattern. He died on April 5, 1976, at age 70, on a flight from Mexico to Houston. While kidney failure was the official cause, doctors cited chronic neglect. His autopsy revealed he weighed just 93 pounds with lethal codeine levels.
After his death, Raymond Fowler of the American Psychological Association conducted a psychological autopsy for estate purposes, reconstructing Hughes's mental state through available records. Hughes's Nevada land holdings eventually became Summerlin, a major planned community outside Las Vegas, representing one of his most tangible legacies. During his Las Vegas tenure, the mob skimmed approximately $50 million from his casinos, though this didn't significantly impact his legendary fortune.
1-Page Summary
Howard Hughes's life in his later years is marked by escalating mental illness, reclusiveness, and a pattern of obsessive and compulsive behaviors, with his stay at the Desert Inn in Las Vegas offering a particularly vivid case study of his decline.
By 1961, Howard Hughes had vanished from public view, having already become severely impacted by mental illness and substance abuse. In 1966, at age 59, he was covertly transported by private train to Las Vegas’s Desert Inn Hotel and Casino, where he took up residence on the entire ninth floor. Having not been seen publicly for five years, he had lost dozens of pounds and four inches of height due to physical neglect and opioid addiction that originated after a serious plane crash left him in chronic pain. His addiction accelerated throughout the 1950s, further isolating him and propelling a rapid decline in both physical and mental health.
Within the Desert Inn, Hughes transformed his living quarters into a dark, isolated warren. He sealed the windows with heavy curtains, never once opening them. Housekeepers discovered these drapes had rotted in place after he finally vacated the floor. Hughes refused nearly all staff contact, denying housekeeping for four years except possibly a single visit. During this period, he subsisted on a diet of candy bars, very sweet canned fruit, and milk, which left him malnourished and anemic.
The combination of his refusal to allow room cleaning and poor dietary choices meant Hughes’s health deteriorated dramatically while at the Desert Inn. His compulsion for isolation intensified both his physical decline and the squalor in which he lived.
Hughes suffered from an extreme, idiosyncratic form of obsessive-compulsive disorder (OCD) marked by contamination fears focused on other people's germs while disregarding his own. He rarely bathed, at times only once a year, and quit attending to basic personal hygiene, allowing his hair and fingernails to grow unchecked. He feared tap water, drinking only bottled water, and was convinced that any outside intrusion could bring contamination.
Staff, including secretaries who prepared correspondence for him, had to adhere to rigorous and unusual protocols. They wore gloves when typing documents intended for Hughes, and he issued exhaustive instructions on how to use tissues—requiring staff to use exact numbers of tissue sheets to touch and handle various objects or doors that might come into his presence.
Tissues and tissue boxes became central to his self-imposed barrier against contamination. He famously used tissue boxes as makeshift slippers, believing the boxes’ sterile nature would shield him from germs. There is photographic and cultural evidence of this, including lampooning in media like "The Simpsons" and recreation in films such as "The ...
Howard Hughes's Mental Illness and Reclusive Behavior
Howard Hughes played a pivotal role in reshaping Las Vegas through a wave of high-profile casino and hotel acquisitions, ultimately shifting the city’s reputation from a mob-controlled gambling den to a respectable, corporate destination.
In 1966, Howard Hughes arrived in Las Vegas at the Desert Inn, seeking a tax shelter after selling all his TWA stock and facing a substantial tax bill. Hughes initially intended to stay just over a week, but he kept extending his stay, occupying an entire floor. Hotel management, facing pressure to prepare for New Year's Eve, asked him to leave. Even Jimmy Hoffa reportedly advocated for Hughes to remain, reflecting his influence, but ultimately hotel staff prepared to remove him.
Instead of leaving, Hughes followed the suggestion of his right-hand man, Robert Maheu, and bought the Desert Inn outright for $13.25 million. In a typical Hughes move, he simply instructed his staff to purchase the hotel so he wouldn’t have to vacate his suite. With this unexpected acquisition, Hughes entered the casino business.
From 1966 to 1968, through his Summa Holding Corporation, Hughes bought six major Las Vegas casino-hotels, almost all from mob-connected owners: the Desert Inn, Sands, Castaways, Silver Slipper, Landmark, and Frontier. His acquisition of the Landmark was driven by rivalry with Kirk Kerkorian’s International Hotel; Landmark’s 31 floors would outdo the International’s 30, so Hughes ensured a grand opening just before his competitor’s.
Hughes attempted to purchase a seventh casino, but his growing influence triggered a federal antitrust lawsuit. The government intervened, concerned about the formation of a monopoly in Las Vegas gambling, and barred Hughes from additional acquisitions. By the end of 1968, his collection of six casinos marked the limit of his Las Vegas empire.
Hughes was not motivated solely by financial gain. He envisioned transforming Las Vegas into a legitimate, corporate-friendly city, potentially even welcoming families in the future. As a germaphobe and futurist, he imagined a smog-free, environmentally conscious city with efficient governance, insulating taxpayers from exploitation. Hughes believed Las Vegas could shake its ...
Hughes's Transformation of Las Vegas Through Acquisitions
Howard Hughes, an eccentric billionaire, relied on a complex system of trusted associates to manage his business and personal affairs, compounding his extreme isolation and enabling his increasingly bizarre demands.
Robert Mayhew served as Hughes's chief of security and public representative for eight to fifteen years, even acting as a confidant despite never meeting Hughes face-to-face. Mayhew communicated with Hughes only via phone calls, exchanged memos, and occasional conversations through a door. Remarkably, this lack of direct contact did not impede Mayhew’s significant influence; he frequently made decisions on Hughes’s behalf, negotiated with officials and leaders, and committed to enormous purchases all based on instructions relayed through this remote, indirect system. There are accounts that Mayhew may have impersonated Hughes on the telephone and essentially "ran the show," although always following Hughes’s minute, meticulous orders.
The communication and logistics connecting Hughes and Mayhew were facilitated by a group of six men, five of whom were Mormon and thus nicknamed the "Mormon Mafia." Chosen for their trustworthiness and adherence to religious prohibitions against drinking, smoking, and gambling, these men served as Hughes’s only personal contacts during his period of extreme reclusion. The "Mormon Mafia" handled an array of functions: they conveyed memos and notes between Hughes and Mayhew, provided Hughes with [restricted term] injections (though he often did that himself), and catered to his obsession with cleanliness—always using wads of tissues when interacting with him. They alone witnessed Hughes’s physical and mental decline up close, maintaining his strict isolation from the outside world while scrupulously delivering instructions, materials, and daily necessities.
The Support System Managing Hughes's Affairs and Isolation
Howard Hughes’s later years in Las Vegas reveal a pattern of controversial, often discriminatory, ideological positions paired with quixotic political plans. Despite immense personal influence and the power that came with his wealth, Hughes’s proposals frequently reflected a desire for control, resistance to social progress, and personal privilege rather than societal benefit.
In September 1968, Hughes attempted to cancel the first annual Desert Inn Invitational Tennis Tournament after learning that Arthur Ashe, an African American, would compete. Hughes feared the presence of Black fans at his casino and worried about potential upheaval or damage. He pressured his lieutenant, Mayhew, to call off the high-profile event out of these racist concerns. However, Mayhew resisted, arguing the tournament should proceed.
In a noteworthy turn of events, Arthur Ashe not only competed but won the singles title at the tournament, achieving a symbolic victory over Hughes’s attempt to maintain discriminatory practices in his casino.
Hughes pushed for a range of policy changes, many reflecting both dated and disturbing worldviews. He proposed repealing sales, gas, and cigarette taxes, a move with populist appeal. However, he also advocated for keeping Clark County schools segregated, supporting racist educational policy. He sought to prohibit the booking of talent from communist countries—reflecting cold-war era fears—and wanted to outlaw rock festivals. Notably, he insisted that dog racing remain illegal, though the reason for this is unclear.
Hughes also demanded extraordinary personal privileges and controls. He wanted to be legally exempt from appearing in court or before any board under any circumstances, ensuring he could avoid public appearances and oversight. Additionally, he attempted to mandate that Las Vegas or Clark County authorities consult with him before realigning any street, reinforcing his penchant for controlling the public realm and preventing unpredictable changes to his environment.
Hughes's Controversial Ideological Positions and Political Proposals
Howard Hughes, after four years at the Desert Inn, decided he had enough of Las Vegas. On Thanksgiving Eve, 1970—four years to the day after his arrival—Hughes left the city under the cover of night. So debilitated he could not walk, he was carried out on a stretcher down a fire escape, taken to an airplane, and flown to the Bahamas. There, at the Xanadu Beach Resort, Hughes established a similar reclusive existence, camping out for years and eventually overstaying his welcome.
Hughes died on April 5, 1976, on a plane flight from Mexico to Houston at the age of 70. The official cause of death was kidney failure. However, doctors remarked that chronic neglect led to his condition. The autopsy revealed he weighed only 93 pounds and had a codeine concentration high enough to stop five beating hearts.
Psychological Autopsy by Raymond Fowler After Hughes's Death
News of Hughes’s death shocked the world, especially as details of his physical state emerged. Accounts described alarming weight loss, with Hughes leaving his room only three times during his four-year residency in Las Vegas—all for business meetings. On those rare occasions, he would shave, wash, cut his hair and nails, which otherwise grew unchecked. His extreme isolation and self-neglect became widely known after his death.
After Hughes died, the division of his estate among 11 or 12 inheritors prompted a group to hire the head of the American Psychological Association, Raymond Fowler, to conduct a psychological autopsy. Fowler reviewed all available records and evidence to establish a psychological profile of Hughes, reconstructing his mental competence and psychological state in his final years. Despite ethical concerns over posthumous diagnosis, Fowler's work provided a rare and influential psychological sketch based strictly on the evidence, enhancing public understanding of Hughes’s decline.
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Hughes's Deterioration and Legacy After Death
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