In this episode of Stuff You Should Know, hosts Chuck Bryant and Josh Clark examine seasonal affective disorder (SAD), a form of depression that typically occurs during specific seasons. They break down the disorder's symptoms, noting the differences between winter-onset SAD (characterized by oversleeping and increased appetite) and its less common spring/summer variant, while explaining how SAD affects roughly 5% of the U.S. population.
The hosts explore the biological mechanisms behind SAD, including how reduced sunlight affects serotonin production and circadian rhythms. They discuss various risk factors, from geographic location to genetic predisposition, and examine why certain populations—such as women and people living far from the equator—may be more susceptible to developing SAD than others. The episode also addresses how psychological factors and attitudes toward seasonal changes can influence the condition's severity.

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Chuck Bryant and Josh Clark discuss seasonal affective disorder (SAD), a form of depression that typically occurs during specific seasons, most commonly winter. While winter-onset SAD is characterized by oversleeping, increased appetite, weight gain, and social withdrawal, the hosts explain that a less common spring/summer variant exists with opposing symptoms, including insomnia and decreased appetite.
The disorder is classified as major depression with a seasonal pattern, affecting about 5% of the U.S. population. Bryant notes that for a clinical diagnosis, symptoms must appear for at least two consecutive years, though not necessarily every year. Notably, women are four times more likely to develop SAD than men, possibly due to hormonal fluctuations.
Clark explains that SAD's biological mechanisms center around serotonin and circadian rhythms. During winter, reduced sunlight leads to lower serotonin production, but unlike in non-SAD individuals, those with SAD don't experience a proportional decrease in serotonin transporters, creating an imbalance that triggers depression.
Bryant cites a 2023 German study showing that seasonal changes affect sleep cycles even with artificial light present. The hosts discuss how decreased winter sunlight increases melatonin production, contributing to lethargy and reduced activity levels, which can worsen SAD symptoms.
According to Clark, living farther from the equator increases SAD risk due to fewer daylight hours, though Bryant notes some interesting exceptions, such as Trumsa, Norway, where despite two months without sunlight, SAD rates remain surprisingly low.
The hosts discuss genetic factors, explaining that carrying certain variants of the serotonin transporter gene can increase vulnerability to SAD, especially during winter. Additionally, having relatives with SAD or other mood disorders raises one's risk of developing the condition.
Bryant and Clark explore how psychological factors, such as negative attitudes toward winter and anxiety about approaching seasonal changes, can create feedback loops that amplify SAD symptoms. They note that maintaining a positive view of winter activities might help mitigate these effects.
1-Page Summary
Seasonal affective disorder (SAD) is a depressive condition tied to seasons, typically manifesting in winter, though it can also occur in summer. Chuck Bryant and Josh Clark discuss how SAD often begins in the fall or early winter and tends to subside when spring arrives. When symptoms persist for days, particularly during winter, it may be a sign to consult a medical professional.
Winter-onset SAD, which is more common, includes symptoms such as oversleeping, craving for carbohydrates, overeating, weight gain, fatigue, low energy, and social withdrawal. These symptoms can create a feedback loop exacerbating depression.
The less common spring and summer variant of SAD includes symptoms opposite to those of winter SAD, such as trouble sleeping (insomnia), reduced appetite, weight loss, and feelings of anxiety, agitation, and irritability. Clark suggests that the increase in energy during these warmer seasons may be related to a higher incidence of suicide in spring and summer.
SAD is identified in the DSM as a major depressive disorder with a seasonal pattern. While about 5% of the U.S. population experiences severe depressive symptoms in the winter months due to SAD, Brya ...
Symptoms and Types of Seasonal Affective Disorder
The biological underpinnings: of Seasonal Affective Disorder (SAD) are multi-faceted, with serotonin and circadian rhythms playing significant roles in its development.
SSRIs, a treatment for SAD, target serotonin levels, highlighting serotonin's role in the disorder. Josh Clark explains that sunlight boosts serotonin production, and thus, lower winter sunlight leads to decreased serotonin levels. In most individuals, serotonin transporters decrease in winter to help maintain mood; however, this adjustment is ineffective in those with SAD.
People with seasonal affective disorder maintain stable serotonin levels throughout the year, but during winter, these levels drop without a proportional decrease in serotonin transporter proteins. This results in serotonin being removed more quickly than it should be, leading to depressive symptoms associated with Seasonal Affective Disorder.
The suprachiasmatic nucleus (SCN), located in the hypothalamus, plays a crucial role in regulating circadian rhythms, which are influenced by light exposure. Melatonin production is triggered when sunlight hits the retinas and sends signals to the SCN. This process subsequently influences the pineal gland, based on environmental cues, especially light.
A 2023 German study cited by Chuck Bryant found that sleep cycles change with seasons even under ar ...
Biological Causes of Seasonal Affective Disorder
Josh Clark and Chuck Bryant delve into the risk factors and contributors to Seasonal Affective Disorder (SAD), considering both genetic and environmental aspects as well as the psychological response to seasonal changes.
Clark mentions that being further from the equator, and hence at a higher latitude, raises the likelihood of having seasonal affective disorder due to fewer daylight hours. Particularly in places far from the equator or in locales like Seattle, which experiences a high number of gray days, people are more susceptible to SAD.
Bryant discusses the findings of a meta-analysis showing that with each one-degree increase in latitude, which results in fewer daylight hours, the rates of Winter SAD increase. An interesting counterpoint is brought up with the example of Trumsa, Norway—a northern city with no sunlight for two full months—and yet, its inhabitants have much lower rates of SAD than might be expected.
The hosts discuss the genetic linkage to SAD, noting that having family members with depression or other mental health disorders may raise the risk of developing seasonal affective disorder. Specifically, individuals carrying at least one short allele in the serotonin transporter gene promoter region tend to be more vulnerable to depression. During winter, heightened levels of serotonin transporters are associated with this genetic variant, subsequently increasing the risk of SAD.
Having a close relative with SAD or another mood disorder significantly raises the likelihood of one developing SAD, highlighting the hereditary component of this condition.
Bryant remarks that general feelings of negativity during winter reflect a broader psychological tendency that can amplify SAD symptoms. Clark suggests that this negativeness may ...
Risk Factors and Contributors to Seasonal Affective Disorder
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