In this Huberman Lab episode, neuroscientist David Eagleman explores how the brain changes and learns throughout life. He discusses the unique capabilities of the human prefrontal cortex, explains how early experiences shape brain development, and describes how stress and novelty affect our perception of time and formation of memories.
Eagleman delves into research about group identity and polarization, revealing how our brains respond differently to people we consider part of our "in-group" versus "out-group." He also examines the function of dreams, particularly their role in brain maintenance and development, and explains how dream experiences can vary among different individuals, including those who are blind or have aphantasia.

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David Eagleman explains that our brain's 86 billion neurons are constantly making and breaking connections, allowing us to adapt to our environment. This flexibility enables learning and growth throughout life. Andrew Huberman emphasizes the importance of engaging in challenging tasks to enhance this adaptability, particularly during childhood.
The human prefrontal cortex, which is four times larger than in other animals, allows us to simulate potential futures and make complex decisions. Eagleman notes that this additional "computational real estate" enables sophisticated processing and learning capabilities unique to humans.
Early experiences significantly shape brain development. Eagleman describes how identical genetic makeup can result in different brain configurations based on cultural context and experiences. For instance, when someone is born blind, the brain repurposes the visual cortex for other sensory processing.
Through innovative experiments, Eagleman discovered that while time doesn't actually slow down during stressful situations, our memories of these events become more detailed. The amygdala signals the importance of stressful events, leading to denser memory formation and the illusion of time dilation.
Time perception is also influenced by the novelty of experiences. Eagleman explains that new experiences create more detailed memories, making time feel longer, while routine activities make time seem to pass quickly. This phenomenon explains why time appears to speed up as we age, as we typically encounter fewer novel experiences.
Neuroimaging research reveals that our brains show stronger empathic responses to in-group members than to out-group members. Eagleman's lab demonstrated that even arbitrary group assignments could trigger these biases. Dehumanizing language can exacerbate these divides by reducing empathic responses toward other groups.
To counter polarization, Eagleman suggests fostering common ground between groups and promoting critical thinking through exposure to multiple perspectives. He proposes using AI in education to facilitate understanding of different viewpoints.
Dreams serve crucial functions in brain maintenance. During sleep, dreaming helps protect the visual cortex from being overtaken by other senses. Eagleman notes that species with greater brain plasticity and longer infancy periods experience more REM sleep, suggesting its importance in learning and development.
The visual experience of dreaming varies among individuals. Blind people dream using non-visual senses, while those with aphantasia may have different dream experiences altogether. During REM sleep, the brain creates narratives and emotions, weaving various sensory inputs into coherent stories, regardless of their origin.
1-Page Summary
The hosts discuss neuroplasticity—the brain's remarkable capacity to reorganize itself by forming new neural connections throughout life. This adaptability is a response to learning, experience, and even injury.
David Eagleman notes that the brain constantly reconfigures itself, with 86 billion neurons always moving around, making and breaking connections, searching for new connections, and altering the strength of their synapses. This flexibility allows humans to absorb everything in their world and makes them highly adaptable, enabling us to thrive in various environments.
Experience and deliberate learning are pivotal in neuroplasticity. Andrew Huberman discusses the importance of engaging in diverse activities during childhood to leverage neuroplasticity and how choices and feedback can direct the career paths we follow, further influencing our brain's plasticity. Eagleman explains the importance of continually challenging the brain to learn new skills and information, underscoring that ongoing challenge is essential for adaptation.
The hosts explore the role of the prefrontal cortex in human evolution and technological progress, noting its capacity to simulate futures—a critical ability to predict outcomes without risk and to make informed decisions. Eagleman describes how we spend much of our time not in the present but reminiscing or simulating possible futures, a mental simulation made possible by our expansive prefrontal cortex.
Human brains contain four times as much cortex as other animals, providing a vast computational space that allows for complex processing. This additional space allows humans more options and the ability to weigh decisions. Eagleman points out that our significant prefrontal cortex grants us a substantial capacity for processing and complex learning.
Eagleman explains that different times and cultures give rise to different brain configurations in people with the same DNA, resulting in unique languages, stories, and experiences. He also discusses how being born blind or deaf can lead to the repurposing of the cortical area that would normally be used for vision or hearing.
Specialization and the paths people take in life result from genetic predispositions and childhood experiences, which we do not choose, and are significantly influenced by the era and cultural context into which one is ...
Neuroplasticity and the Brain's Ability to Change
Research and experiments in the field of psychology reveal complex relationships between our experiences of stress, the passage of time, and the memories we retain.
Eagleman's investigation focuses on whether or not our perception of time genuinely slows down in life-threatening situations.
David Eagleman devised an experiment involving subjects dropping from a 150-foot tower to assess if people perceive events in slow motion during life-threatening scenarios. The finding was that the frame rate of perception does not increase, and people do not take in information faster. However, the density of memory becomes higher under stress, creating a sense of extended duration for those stressful or traumatic events. For example, Eagleman recalls a personal incident from his childhood where a fall off a roof seemed to take an unusually long time due to the increased attention to detail, and consequently, the creation of denser memory for the event.
In emergency situations, the amygdala signals the importance of the event, leading to heightened focus and a denser memory of the stressful event. This increased recording of details leads the brain to estimate that more time must have passed than actually did. A motorcycle accident, for instance, may seem to take much longer than footage later reveals.
Eagleman discusses how our perception of time changes based on the novelty or familiarity of the experiences we encounter.
Novel activities lead to the recording of more memories, making the time spent on those activities feel longer. Spending a weekend parasailing, for instance, leads to a feeling that a substantial amount of time has passed since the previous workday.
Conversely, weekends spent on routine activities like browsing Instagram can feel fleeting due to a lack of new memories.
Eagleman suggests that time seems to speed up as we age not because a year is a smaller fraction of our life, but because we tend to have fewer novel experiences. He advises seeking novel experiences to enhance the perception of a longer lifetime, such as rearranging one’s office or taking different routes home.
Time Perception, Stress, and Memory
David Eagleman and Andrew Huberman delve into the neurological underpinnings of human behavior, specifically focusing on how the brain's wiring can lead to in-group favoritism and out-group hostility, as well as strategies to mitigate the effects of polarization.
The discussion opens with Eagleman reflecting on experiments that illustrate our innate senses of fairness and empathy, which can be highly selective based on group identity.
Using neuroimaging, researchers found that empathic brain responses in the pain matrix were stronger when participants observed harm coming to members of their own group. Labels such as religious affiliations on hands being stabbed with a syringe needle influenced the intensity of the empathic response, thus highlighting the impact of perceived group membership on empathy.
Eagleman’s lab conducted an experiment where participants were randomly assigned to groups—Justinians or Augustinians—and given corresponding wristbands. The study revealed that participants exhibited a stronger empathic brain response to their assigned in-group, despite the distinctions being arbitrary. This indicates that biases can occur even with superficial group distinctions.
Eagleman explains how elements like dehumanizing language can deepen divides between groups, while Huberman comments on more subtle ways that biases and group dynamics play a role in daily life and decision-making.
Eagleman discusses the dangerous consequences of dehumanizing language, referring to historical events such as the Rwandan genocide where Tutsis were reduced to "cockroaches" via propaganda. This type of language turns off the networks in the brain that care about human interaction, facilitating acts of violence.
Though not explicitly mentioned, the conversation suggests that without meaningful contact across group divides, people may develop antagonistic views due to a perceived zero-sum mindset regarding resources and opportunities, leading to increased polarization.
The Neuroscience of Polarization and Group Identity
Dreaming is a complex process that serves various functions for our brain, from maintaining cognitive abilities to ensuring our brain regions, such as the visual cortex, remain active.
During the night, in the absence of light, dreaming acts as a method of protecting the visual cortex from overtake by other senses, which would have been an evolutionary disadvantage before the invention of artificial light.
The mechanism behind this protective function involves the dream circuitry, which includes the midbrain, lateral genicular nucleus, and the primary visual cortex. This system activates only the visual cortex approximately every 90 minutes to defend its territory and maintain the sense of sight as primary.
Research across 25 primate species shows a correlation between REM sleep and brain plasticity. Species with more extended infancy periods, such as humans, who learn slowly and have highly plastic brains, experience more REM sleep. This sleep state is predominant in infancy and decreases as the brain becomes less plastic over time. In contrast, species born with more maturity, like cows and zebras, which are mobile shortly after birth, have much less REM sleep. The given hypothesis is that dreaming, especially during REM sleep, is essential for learning and interaction with the environment during developmental stages.
The visual experiences during dreams can vary greatly from person to person, particularly for those who are blind or have aphantasia.
David Eagleman explains that the visual cortex in people born blind adapts to process information from other senses such as hearing and touch. This adaptability is exemplified by the use of devices like BrainPort, which allows blind users to "see" through electrical signals on their tongue. These users can navigate obstacles and perform tasks like handling a ball, showing their brain's ability to interpret non-visual information. In dreams, blind people may use auditory cues for navigation or experience sensations like moving around objects or sensing animals, which emphasizes their reliance on non-visual sensory experiences.
Eagleman also discusses aphantasia, where individuals can't create images in their minds. Interestingly, many of Pixar's top directors and animators share this condition, which mi ...
The Purpose and Mechanisms Of Dreaming
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