In this episode of the Huberman Lab podcast, Dr. Kyle Gillett and Andrew Huberman explore hormone health optimization and its effects on overall wellness. They discuss the importance of proactive hormone monitoring through regular blood tests and explain how lifestyle factors like diet, exercise, stress management, and sleep impact hormone levels.
The conversation covers hormone-related health conditions, including PCOS and testosterone deficiency, along with their treatments and management strategies. Dr. Gillett and Huberman examine the relationship between hormones and various aspects of life, from growth hormone production during sleep to the role of hormones in relationship dynamics. They also address how substances like alcohol and marijuana can affect hormone balance, and how major life events influence hormonal changes.

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Dr. Gillett and Andrew Huberman discuss the importance of proactive hormone health assessment and optimization. Dr. Gillett advises monitoring changes in energy, focus, and athletic performance over time, rather than waiting for obvious health issues to develop. He recommends comprehensive blood tests every three to six months, emphasizing the importance of testing both fasting and non-fasting samples.
Diet and exercise play crucial roles in hormone health. Dr. Gillett explains that while caloric restriction can benefit those with metabolic syndrome, it might decrease [restricted term] in young, healthy individuals. Huberman adds that 150-180 minutes of zone two cardio exercise weekly supports overall health.
The experts emphasize that stress management and quality sleep are essential for hormonal balance. They warn against substance use, noting that alcohol, marijuana, and certain medications can disrupt hormone levels. Gillett points out that spiritual well-being is also crucial for optimal hormone function.
Dr. Gillett discusses Polycystic Ovary Syndrome (PCOS), explaining that it typically presents in women's 30s with symptoms including androgen excess, [restricted term] resistance, and irregular cycles. Management often focuses on treating metabolic syndrome through body composition optimization and [restricted term] sensitization.
Regarding [restricted term] replacement therapy, while it can benefit men with deficiencies, the experts note that careful monitoring is necessary, especially for conditions like sleep apnea. They clarify that while [restricted term] doesn't cause prostate cancer, it could potentially accelerate existing cancer growth.
[restricted term] levels, which naturally spike overnight, can be optimized through intermittent fasting, according to Gillett. He suggests that avoiding food before sleep can enhance [restricted term] levels and improve overall health.
Dr. Gillett explains how hormones like prolactin and pheromones influence relationship dynamics. He recommends incorporating intentional periods of separation and reconnection in relationships to maintain hormonal harmony, particularly during long-term cohabitation. He also stresses the importance of planning for hormonal changes that accompany major life events like pregnancy and breastfeeding.
1-Page Summary
Dr. Gillett and Andrew Huberman stress the significance of proactive and contextual hormone health assessments to optimize well-being and performance.
Dr. Gillett advises to monitor changes in energy, focus, and athletic performance over time. He suggests evaluating hormone health by comparing these aspects to how one felt in the past, rather than waiting for a pathological condition to manifest.
Kyle Gillett emphasizes the importance of blood tests for comprehensive insights into hormone levels, recommending them every three to six months. These tests should be adapted to individual needs and symptoms. He highlights that such regular testing should include both fasting and non-fasting samples for a more thorough understanding and encourages open communication with healthcare providers to facilitate the appropriate tests.
Gillett strongly advocates for testing [restricted term] levels in women to capture the full spectrum of hormonal activity. Even though women are thought to have low [restricted term] levels, free [restricted term]—which is not bound and constitutes the smallest fraction of total [restricted term]—is primarily measured.
Gillett clarifies that sex hormone-binding globulin (SHBG) preferentially binds androgenic steroids, with a stronger affinity for dihydrotestosterone (DHT) and [restricted term], and a lesser affinity for estrogens like [restricted term], making it imperative to consider this in hormone assessments.
Dr. Gi ...
Assessing and Optimizing Hormone Health
Experts like Kyle Gillett and Andrew Huberman discuss how certain lifestyle choices can significantly influence hormone health and balance.
Diet and exercise are essential pillars for maintaining hormonal health, with resistance training playing a crucial role. Gillett explains that caloric restriction may be beneficial for those suffering from metabolic syndrome, contributing to a healthier lifespan and improved [restricted term] levels. However, he warns that in young, healthy individuals, it might have the opposite effect, potentially decreasing [restricted term].
Gillett also stresses the importance of an individualized approach to diet, indicating that genetic testing could be helpful in optimizing dietary choices based on personal tolerances and genetics. Huberman adds to the conversation by mentioning that a general baseline of 150 to 180 minutes of zone two cardio exercise per week is recommended for overall health.
Stress optimization is crucial for hormonal balance and overall health, affecting mental well-being and cortisol levels. Huberman highlights the importance of sleep optimization for the health of mitochondria—essential components of our cells that help generate energy.
Sunlight, moving outdoors more, and experiencing temperature variations like cold and heat exposure also contribute to hormone health. Spiritual health completes the holistic approach, as Gillett notes that without spiritual well-being, other optimized factors will not fully benefit the body and mind.
The Impact of Lifestyle Factors on Hormones
Discussion into various hormone-related health conditions provides insight into possible interventions and considerations.
Most women find out they have PCOS in their 30s, and it's on a spectrum with varying severities. According to the Rotterdam criteria, symptoms of PCOS include androgen excess, which can lead to androgenic acne, hair growth on the chin known as hirsutism, deepening of the voice, and male pattern baldness, as well as [restricted term] resistance, which is associated with obesity, pre-diabetes, a high fasting [restricted term], and HOMA IR over two or fasting [restricted term] over six. Another common sign is oligomenorrhea, defined as over 35-day intervals between periods or fewer than nine periods a year. Additionally, infertility issues can be a presenting complaint of PCOS.
Managing PCOS often involves treating metabolic syndrome by optimizing body composition and decreasing body fat. Tools for [restricted term] sensitization include the use of [restricted term] and inositol—specifically, myoinositol for [restricted term] sensitivity and d-chiroinositol as a weak anti-androgen.
[restricted term] replacement can benefi ...
Hormone-Related Health Conditions and Interventions
Emerging research sheds light on the intricate connections between hormonal balance, sleep quality, and overall growth, highlighting the importance of these factors in maintaining good health.
Gillett discusses the pivotal role of [restricted term] in the context of sleep and overall health, indicating that [restricted term] levels are closely tied to both.
He explains that [restricted term], which naturally spikes overnight, can be improved through intermittent fasting, especially benefitting older age groups. Additionally, he suggests that refraining from eating in the hours before sleep can further enhance [restricted term] levels and subsequently improve overall health and sleep quality.
The Connection Between Hormones, Sleep, and Growth
Interpersonal dynamics play a significant role in hormone balance, particularly through mechanisms such as hormonal crosstalk.
Pheromones and hormones such as prolactin are integral in shaping our interpersonal dynamics and overall well-being. Prolactin, which is closely related to estrogen, can directly influence relationships; as elevated levels of estrogen upregulate the PRL gene, this upregulation increases prolactin synthesis. Elevated prolactin can in turn inhibit the release of [restricted term] from the pituitary gland. Moreover, modifying [restricted term] levels can also alter prolactin levels, as utilizing a [restricted term] agonist can decrease the production of prolactin cells.
If concerned about high levels of prolactin, it might be recommended to remove elements that could be escalating its levels, including certain dietary components like casein or gluten, both of which act as mu opioid receptor agonists.
An interesting phenomenon connected to hormonal crosstalk is that the menstrual cycles of women who spend considerable time together may synchronize due to pheromonal and hormonal influences that include prolactin.
Kyle Gillett recommends certain strategies to maintain hormonal harmony in relationships, in particular during times of potential hormonal shifts due to long-term cohabitation.
The Influence of Social/Relational Factors on Hormones
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