In this Huberman Lab episode, Dr. Glen Jeffery and Andrew Huberman explore the effects of different light wavelengths on human biology. They examine how short wavelengths, particularly from LED lights, can potentially harm cellular structures and DNA, while longer wavelengths like red and infrared light can enhance cellular function and improve mitochondrial health.
The discussion covers research findings about the benefits of red light exposure, including improvements in visual function and metabolic regulation, as well as the potential health risks associated with excessive LED light exposure. Huberman and Jeffery address practical strategies for optimizing indoor and outdoor lighting environments, including the importance of natural sunlight exposure and alternatives to LED lighting for indoor spaces.

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In a discussion between Andrew Huberman and Glen Jeffery, they explore how different light wavelengths affect human biology. Sunlight contains a complete spectrum from ultraviolet (300 nanometers) to infrared (3000 nanometers), with visible light falling between 400-700 nanometers.
According to Dr. Jeffery, high-energy short wavelengths, particularly those from LED lights, can damage cellular structures and DNA. He suggests a possible connection between increased LED usage and a plateau in human lifespan growth. Conversely, longer wavelengths like red and infrared light enhance cellular function by improving mitochondrial health and ATP production.
Glen Jeffery shares remarkable findings about the benefits of red and infrared light exposure. In his research, just three minutes of exposure to 670-nanometer deep red light improved visual function by 20%, with effects lasting five days. This therapy shows particular promise for early intervention in vision-related conditions.
Huberman and Jeffery discuss how long wavelength light exposure can improve metabolic regulation. Their research shows that red light exposure can reduce blood glucose spikes by over 20%, suggesting broader implications for systemic health through mitochondrial stimulation.
Dr. Jeffery warns that LED lights, which are rich in short wavelengths, can significantly impair mitochondrial performance. In their experiments, mice exposed to LED lighting showed poor glucose metabolism, leading to weight gain and liver problems. Jeffery compares the potential public health impact of widespread LED adoption to the asbestos crisis, emphasizing the urgency of addressing this issue.
Both experts emphasize the importance of natural sunlight exposure for optimal health. Jeffery points to research showing lower all-cause mortality in people who receive adequate sunlight. For indoor environments, they recommend using incandescent or halogen bulbs, which provide a more natural, full-spectrum light compared to LEDs. Jeffery also notes that the presence of plants near windows can help reflect beneficial infrared light indoors, potentially offsetting the limitations of modern building materials that block these wavelengths.
1-Page Summary
Andrew Huberman and Glen Jeffery delve into the biological impacts of different light wavelengths, revealing a sharp contrast between the effects of high-energy short wavelengths and the benefits of red and infrared long wavelengths.
Sunlight offers a spectrum of light that goes beyond what the human eye can see, ranging from ultraviolet (around 300 nanometers) to infrared (out to nearly 3000 nanometers). The visible spectrum sits between 400 to 700 nanometers. Incandescent lights provide a smooth spectrum similar to sunlight, without the peaks and valleys found in the light emitted by LEDs.
Short wavelengths of light, especially ultraviolet rays just below the visible blue spectrum, are potent in energy and can cause cellular damage. Excessive exposure brings about an inflammatory response in the skin, like sunburn, and can cause serious conditions such as snow blindness or cataracts due to the harm they inflict on cellular structures.
Dr. Jeffrey draws a correlation between excessive short wavelength light exposure from LED bulbs and screens and mitochondrial damage. Similarly, he suggests a potential link between increased LED use and a flattening out in the growth curve of lifespans.
In contrast, long wavelengths of light such as red, near infrared, and infrared enhance cellular function. These beneficial wavelengths are absorbed by the water within cells' mitochondria helping their function, increasing ATP production, and protecting against damage caused by short wavelength exposure.
Huberman and Jeffery explore the various benefits of long wavelength light. Huberman himself uses red light therapy devices to boost mitochondrial and cellular function and Glenn Jeffery's research supports this practice, showing that long wavelengths can improve mitochondrial health, reduce cell death, and ...
Biological Effects of Light Wavelengths, Short vs Long
Dr. Andrew Huberman and Dr. Glen Jeffery explore the multifaceted health benefits of exposure to long wavelength light, such as red, near-infrared, and infrared light. These benefits include improvements to vision, skin health, blood sugar regulation, and metabolism.
Glen Jeffery shares findings from experiments with 670 nanometers deep red light, where people experienced a 20% improvement in visual function after just three minutes of exposure. This enhanced color vision, particularly the perception of blue and red, lasted for five days. Jeffery suggests the general population, living under predominantly LED lights, may be experiencing suppressed physiology affecting color perception. Andrew Huberman discusses an experimental setup wherein eye exposure to long wavelengths can improve vision, recommending the use of a 670 nm or greater emitting flashlight for three to five minutes once every five days.
Discussing macular degeneration, Jeffery explains that although patients with advanced forms of the disease did not show improvement with red light therapy, their partners without the disease did experience significant vision enhancements. Early intervention with red light is deemed crucial since the therapy is less effective with well-established diseases.
The discussion includes the positive effects of long wavelength light on mitochondrial function. Exposure to red light boosts metabolic regulation, as evidenced by experiments where subjects depicted a blood glucose increase that didn't peak as sharply after exposure, reducing spikes by over 20%. This systemic response to localized mitochondrial stimulation suggests that long wavelength light could have broader health implications.
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The Health Benefits of Long Wavelength Light Exposure
Glen Jeffery explains that when LED light, which is rich in short wavelengths, is used on the retina, mitochondrial performance declines. This suggests that these light sources are harmful to mitochondrial health.
Jeffery does not specifically mention accelerated aging of the retina and vision loss, but his discussion about the poor mitochondrial performance in mice retinas under LED lighting implies the potential for retina damage and vision impact. There is additional reference to the risk of myopia, which may lead to a form of macular degeneration as one ages.
Andrew Huberman indicates that exposure to excessive short wavelength light may alter blood glucose levels detrimentally, affecting metabolism. Experiments show that mice under LED light put on weight due to poor glucose metabolism, leading to fatty livers and indications of liver distress.
While the transcript does not specifically address the impact on circadian rhythms and sleep-wake cycles, Jeffery's work with mice suggests behavioral disruptions, potentially ...
Health Risks of Excessive Short Wavelength Light Exposure
Andrew Huberman and Glen Jeffery underscore the critical role of exposure to natural sunlight for mitochondrial and overall health. Jeffery lauds the findings of dermatologists like Richard Weller from Edinburgh, emphasizing that all-cause mortality is lower in individuals who receive ample sunlight and warning against sunburn.
The podcast reflects on sunlight's offering of a broad spectrum of light, which is superior to the narrow bands provided by artificial sources like LED lights. Jeffery highlights research showing mitochondria produce more ATP in the morning, suggesting the potential health benefits of morning sunlight exposure. Huberman and Jeffery agree that balanced wavelengths in sunlight are ideal for cellular function and discuss the importance of sunlight for healthy mitochondria and reduced mortality.
Glen Jeffery and Andrew Huberman discuss halogen and incandescent bulbs' benefits for providing natural, full-spectrum light that resembles sunlight. Jeffery points out that incandescents, like halogen bulbs, are still available and practical, even essential for purposes where LEDs are unsuitable, such as inside ovens. A study from University College London highlights improved color detection with incandescent light, supporting their importance in environments with harsh LED lighting. Jeffery encourages the use of halogen lamps, particularly in the morning, which emits light across the spectrum and have a positive effect on mitochondria, supporting their place in public health.
No specific strategies for enhancing indoor lighting with infrared-reflective plants and materials to offset the long wavelength light deficiency from indoor LEDs were provided in the podcast excerpt. However, Jeffery suggests that the presence of plants outside windows can reflect infrared light indoors, enhancing the indoor e ...
Strategies For Optimizing Indoor and Outdoor Lighting Environments
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