In this episode of the Huberman Lab, Huberman explores the science behind gratitude and its effects on the brain and body. He discusses how gratitude practices influence specific brain regions, including the anterior cingulate cortex and medial prefrontal cortex, and explains the role of serotonin in creating positive social experiences.
The episode examines research on what makes gratitude practices effective, revealing that receiving gratitude from others creates more significant neural changes than traditional methods like gratitude lists. Huberman describes how the brain distinguishes between genuine and insincere expressions of gratitude, and explains how observing others receive gratitude—or even hearing stories about gratitude—can activate the same neural networks as experiencing it directly.

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Research shows that gratitude is more than just saying "thank you" - it's a complex behavior that significantly affects our brain circuits and body chemistry.
Studies reveal that regular gratitude practice can modify the brain's emotional pathways, reducing anxiety and fear while boosting well-being. According to research, the anterior cingulate cortex and medial prefrontal cortex are particularly active during gratitude experiences, with activation levels correlating to the intensity of gratitude felt. Huberman notes that just 60 seconds of focused gratitude practice can activate these prosocial circuits and create meaningful benefits.
The neurochemical serotonin plays a crucial role in gratitude, released from the brainstem's RAFA nucleus. This chemical enhances neural circuits that encourage positive social interactions and experiences.
Huberman explains that traditional practices like gratitude lists often fall short of creating significant neural and chemical changes. Instead, receiving gratitude from others proves more impactful. This was demonstrated in an experiment where coworkers exchanged and read gratitude letters face-to-face, showing strong activation in prefrontal networks during these interactions.
Research indicates that authenticity is crucial - our brains can distinguish between genuine and insincere gratitude, with only sincere expressions triggering positive neural responses. Interestingly, Huberman points out that even observing others receive gratitude can activate our prosocial neural networks. This extends to hearing powerful stories of support and kindness, which can trigger the same brain regions associated with directly receiving gratitude, particularly when we feel connected to the story being told.
1-Page Summary
Gratitude is not just a social nicety but a complex prosocial behavior significantly affecting both the mind and body through its influence on neural circuits and neurotransmitter systems.
The study, "Effects of Gratitude Meditation on Neural Network Functional Connectivity and Brain-Heart Coupling," reveals that repeated gratitude practice can profoundly affect the brain. It does so by modifying the functional connectivity of emotion pathways, making anxiety and fear circuits less likely to be active, and increasing the activity in circuits for feelings of well-being and motivation.
Gratitude practices are linked to the activation of prosocial circuits within the brain, which facilitate closeness to oneself and others and are active during positive interactions. Such practices can reduce activity in circuits associated with defensive behaviors, making prosocial behaviors more of a default state, thus enhancing one's mental and physical health.
The anterior cingulate cortex and medial prefrontal cortex are two central areas that serotonin systems activate when individuals experience gratitude. The intensity of gratitude is scaled with the level of activation in these regions, which are further connected to networks invoking thought processes. These processes might lead to thoughts of wanting more of this positive experience and recognizing the good feeling it delivers.
In discussing the medial prefrontal cortex, Andrew Huberman highlights its significance in evaluating different types of experiences and setting context for their meanings, which is crucial for the feeling of gratitude.
Implementing a gratitude practice can quickly shift the activation of pro-social behaviors, as well as circuits in ...
The Neuroscience and Neurochemistry of Gratitude
Studies and expert commentary suggest that while listing or reciting things one is grateful for is a common practice, it may not be the most effective way to evoke psychological and physiological changes in the brain and body.
Huberman explains that traditional gratitude practices like making lists or reciting items of thankfulness don't significantly shift neural circuitry or neurochemistry. While these activities are common, they don't seem to have a strong impact on the somatic circuitry that connects the brain and body.
On the contrary, receiving gratitude is identified as being more impactful than expressing it. Huberman points to an experiment where coworkers wrote gratitude letters to each other and then read these letters face-to-face. Brain imaging during this interaction exhibited robust effects on the prefrontal networks — highlighting the significance of receiving gratitude in activating the prefrontal cortex and prosocial brain regions.
Further, Huberman advises that an effective gratitude practice is reflecting on times when someone expressed gratitude towards you, focusi ...
Gratitude Practices and Their Impact on Health
Gratitude practices have been linked to pervasive and long-lasting impacts on subjective well-being, according to scientific findings shared by Huberman. Such intentional practices are reported to bolster feelings of happiness, joy, and meaning in life and can provide resilience against psychological and physiological detriments of past and potential future traumas.
Huberman underscores the necessity of genuine gratitude for unlocking positive health benefits—a sentiment echoed in research. Our neural circuitry is adept at distinguishing genuine gratitude from a feigned one. Studies, such as one titled "Neural Responses to Intention and Benefit Appraisal are Critical in Distinguishing Gratitude and Joy," use functional magnetic resonance imaging (fMRI) to reveal that the brain's response to gratitude heavily depends on the intention behind the gesture.
This authenticity matters because the brain reacts positively only to sincere expressions of gratitude, with genuine thanks activating neural circuits linked to well-being. The sense of gratitude felt by recipients scales with the intention behind the giving. Wholehearted intention from the giver amplifies the recipient's gratitude sensation.
Remarkably, it’s not only direct receipt of gratitude that can activate our prosocial neural networks. Even observing gratitude in others, such as hearing narratives where individuals express or receive thanks, triggers neural circuits involved in prosocial behavior.
Watching powerful stories of support—like a doctor-prisoner providing aid within a genocide context—can activate the same regions of the brain associated with direct ...
The Importance Of Receiving Gratitude Versus Expressing Gratitude
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