In this episode of Good Inside with Dr. Becky, neuroscientist Darby Saxbe shares research demonstrating that fathers experience measurable brain changes during the transition to parenthood—changes similar to those seen in mothers. Saxbe explains how these neural adaptations support parenting capabilities and emphasizes that effective fathering comes from practice and engagement, not innate instinct. The conversation addresses how biological factors may give mothers an early advantage in responding to infant cues, but fathers can develop equal sensitivity with opportunity and encouragement.
The episode also covers postpartum depression in fathers, which often manifests differently than in mothers and frequently goes unrecognized. Saxbe and Kennedy discuss how paternal withdrawal typically stems from feelings of incompetence rather than lack of care, and they emphasize the importance of policies like paternity leave that enable fathers to build parenting skills. The conversation concludes with research suggesting that active parenting provides fathers with life-sustaining meaning and may offer neuroprotective benefits that promote healthier aging.

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Recent research from neuroscientist Darby Saxbe demonstrates that new fathers undergo measurable brain changes resembling those seen in mothers, with adaptations that support the demands of parenting.
A landmark Spanish study found that mothers lose gray matter volume in regions crucial for empathy and parenting during the transition to motherhood. Saxbe explains that this "loss" actually reflects positive neural streamlining, making pathways in the mentalizing network more efficient. Building on this, Saxbe's research scanned fathers' brains before and after their babies were born. By pooling data from U.S. and Spanish studies, her team discovered that fathers also experience gray matter reduction in many of the same brain regions as mothers. Active, hands-on fathers show more pronounced neural changes, indicating that "dad brain" is real and biologically underpinned. This gray matter reduction is likened to childhood brain pruning, where the brain consolidates pathways for quick, efficient responses to a child's needs.
Parenting requires constantly activating the mentalizing network as adults interpret and address a baby's needs. Parents must troubleshoot each cue—is the baby hungry, wet, tired, or uncomfortable? Repeated engagement in these mental tasks strengthens neural connections through practice and problem-solving.
In early parenthood, mothers often respond more quickly to infant cues. Saxbe attributes this not to "maternal instinct" but to biological and practical head starts from pregnancy and breastfeeding. However, research shows that with encouragement and opportunities, fathers can develop sensitivity to infant cues on par with mothers. Early differences are circumstantial, not inherent, and both parents' brains are capable of adapting fully to parenting demands.
Saxbe asserts that "great parents are made not born," emphasizing that effective parenting results from consistent practice and engagement. Neuroscience reveals there is no unique "maternal brain"—instead, humans possess a "parental brain" that can be developed by any gender. Fathers who are motivated and consistently engaged can build the same neural circuitry associated with responsive parenting. Becky Kennedy adds that awkwardness and uncertainty in early parenting are normal indicators of learning something new. Both parents can fumble through parenting—confidence and competence are cultivated through ongoing, repeated practice.
Saxbe emphasizes the need for policies like paternity leave and flexible work arrangements that allow fathers time to engage with their infants. She stresses the importance of empowering couples to view parenting as a shared endeavor, which builds both partners' confidence through mutual support and practice.
Saxbe notes that throughout human history, people parented in communal settings with intergenerational support through allo parenting or cooperative breeding. In modern society, many parents only hold and care for a baby when their own child is born, lacking exposure from a wider support network. This departure from ancestral caregiving leads to a "huge shock" for new parents, affecting both men and women.
New dads report depressive symptoms at about twice the rate of men in the general population. Risk factors include neurobiological changes, sleep disruption, and struggles with identity and parental adequacy. Men often face additional pressures rooted in male socialization, particularly economic and breadwinner pressures. Saxbe's recounting of her husband's stress-induced vision loss highlights how these anxieties can build beneath the surface, largely unnoticed.
Paternal postpartum depression is frequently missed because symptoms differ from maternal depression. Instead of sadness or crying, depressed fathers may display irritability, emotional withdrawal, reluctance to interact with the baby, or intense focus on work. Cultural expectations contribute to lack of recognition, as these behaviors don't fit the common narrative of postpartum depression.
Saxbe shares how her father transformed from a withdrawn, peripheral dad in the 1980s to a primary caregiver after her parents' divorce. He stepped up to cook, clean, manage routines, and became a patient presence in her life. This transformation illustrates that earlier withdrawal was due to inexperience and lack of confidence, not lack of love. Kennedy reinforces that many fathers feel awkward and incompetent with caregiving tasks, leading to avoidance. Withdrawal is often rooted in uncertainty about unfamiliar parenting responsibilities, not indifference.
Kennedy emphasizes interpreting a partner's withdrawal with generosity. Rather than assuming indifference, consider whether withdrawal stems from uncertainty and incompetence. She proposes addressing this by acknowledging the shared learning curve: "This is new for both of us. I know it can be hard to know where to start. Is that going on for you?" This opens the door for learning caregiving skills together and normalizes fumbling as a shared journey.
Saxbe notes that the transition to parenthood is a risk factor for relationship conflict, often from insufficient conversations about each partner's capacities and needs. Clear, generous communication—inviting participation and supporting each other in learning—helps prevent resentment and fosters collaboration.
Saxbe shares how her father found deep meaning in active parenting after divorce, expressing that it became the most meaningful part of his life. Kennedy echoes that for many fathers, active parenting becomes their greatest fulfillment. Saxbe describes meaningful family rituals with her father—Monday movie nights, Friday sundaes, Sunday church—demonstrating how daily caring builds deep father-child bonds.
Saxbe points to research from the UK Biobank showing that individuals with more children tend to have "younger-looking" brains, with neurological age lower than chronological age. This effect holds true for both mothers and fathers. Saxbe suggests these neuroprotective effects may stem from the demanding social integration and family investment required by parenthood, preserving cognitive function and promoting healthier aging.
Kennedy highlights that awkwardness is inevitable when starting something new. Reframing awkwardness as a natural aspect of novelty allows parents to continue learning rather than retreating. She explains that competence comes from accumulated practice or generational transmission. By persevering through today's awkwardness, fathers create a new pathway—making hands-on fatherhood more natural for future generations. Kennedy concludes by emphasizing that parenting is one of life's greatest roles. By investing emotionally and showing up with presence, fathers shape their children's well-being and build the foundation of the future, ensuring that the next generation will find richness and ease in paternity.
1-Page Summary
Recent research overturns the old notion that fatherhood is purely an emotional or symbolic transformation. Neuroscientist Darby Saxbe’s work demonstrates that new fathers undergo measurable brain changes resembling those seen in mothers, with adaptations that support the demands of parenting.
A landmark study from Spain found that mothers lose gray matter volume in regions crucial for empathy and parenting as they transition into motherhood. While the term “gray matter loss” sounds negative, Saxbe explains that it actually reflects a positive streamlining of the brain, making neural pathways in the so-called “mentalizing network” more efficient. This efficiency stems from the intense cognitive exercise that early parenthood demands.
Building on this, Saxbe’s research scanned fathers’ brains before and after their babies were born. By pooling data from fathers in her U.S. study with the original Spanish study, her team discovered that fathers also experience gray matter loss during the transition to parenthood—and crucially, this occurs in many of the same brain regions as mothers. These results show that brain remodeling is not limited to one gender or just mothers. Instead, active and hands-on fathers show more pronounced neural changes, indicating that “dad brain” is real and biologically underpinned.
Gray matter reduction in both parents is likened to the pruning process in childhood, where the brain simplifies and consolidates its pathways, trading a tangle of dirt roads for fast, efficient superhighways. This kind of neural streamlining is foundational for quickly and adeptly responding to a young child’s needs.
Parenting requires hard cognitive work—constantly activating the mentalizing network as adults seek to interpret and address a baby’s needs. Parents must act as detectives, troubleshooting each cue: is the baby hungry, wet, tired, or uncomfortable? Each instance demands rapid reasoning, ruling out possibilities, and experimenting with soothing strategies.
Repeated engagement in these mental tasks strengthens the necessary neural connections. The brain, through practice and problem-solving, gets better at inferring and responding to nonverbal cues. This demanding work persists even as parents enjoy positive interactions with their infants: the emotional reward helps them repeatedly return to this exhau ...
Neuroscience of Fatherhood: Fathers' Brains Undergo Transformations Akin to Mothers', With Gray Matter and Mentalizing Network Changes Supporting Parenting
Darby Saxbe asserts that "great parents are made not born," emphasizing that effective parenting is a product of consistent practice and engagement, not inherent instinct. The belief that mothers are innately wired to be caregivers and know instinctively what a baby needs is challenged by neuroscience, which reveals there is no unique "maternal brain." Instead, humans possess a "parental brain," which can be developed by any gender.
Research shows that fathers who are motivated and consistently engaged in caregiving can build the same neural circuitry associated with responsive and emotionally attuned parenting. Saxbe highlights that the experience of nervousness or uncertainty in fathers is best addressed by active involvement—the act of trying, even awkwardly, is what matters most. Children notice the effort and consistency more than perfection. Becky Kennedy adds that the awkwardness and sense of unnaturalness in early parenting are normal indicators of learning something new, not signs of failure. Both parents can learn, make mistakes, and fumble—confidence and competence are cultivated through ongoing, repeated practice.
Saxbe emphasizes the need for policies, like paternity leave and flexible work arrangements, that allow fathers the time and opportunity to engage with their infants. Such structures are crucial for fostering caregiving skills by giving dads the chance to be present and practice parenting. She also stresses the importance of empowering couples to view parenting as a shared endeavor, not confined by traditional gender roles, which builds both partners' confidence and competence through mutual support and practice. The more involved fathers are, the more their brains and abilities adapt to their child's needs.
Skill Development: Fathers Develop Parenting Skills and Brain Circuitry Through Consistent Practice
New dads report depressive symptoms at about twice the rate of men in the general population. The transition to fatherhood is a risky period for depression, with overlapping risk factors seen in both mothers and fathers. These include neurobiological changes, sleep disruption, struggles with identity, and concerns about parental adequacy—fathers question themselves with thoughts like, "Who am I?" and "Am I cut out to be a parent?" Such internal questioning and adjustment mirror the well-documented psychological shifts for mothers.
However, men often face additional pressures rooted in male socialization. Economic and breadwinner pressures are uniquely intensified for new fathers. Society expects men to be primary income earners, and with the high costs of parenting, many new dads experience heightened stress and worry about providing for their growing family. Darby Saxbe’s recounting of her husband’s experience with stress-induced vision loss highlights how these anxieties can build beneath the surface, largely unnoticed, even as they manifest physically and psychologically. While impending fatherhood is culturally framed as a time of joy, for many men it is marked by uncertainty, invisible transformation, and silent stressors that go unrecognized.
Paternal postpartum depression is frequently missed because its symptoms often differ from those typically seen in maternal depression. Instead of open sadness or crying, depressed fathers may display irritability, emotional withdrawal, reluctance to interact with the baby, or even an intense focus on work—suc ...
Postpartum Depression in Fathers: How It Manifests Differently and Goes Unrecognized
Darby Saxbe shares a personal story of her father, who, during her childhood in the 1980s, embodied the archetype of the peripheral, withdrawn dad, often retreating to his study while her mother managed the demands of parenting. However, when her parents divorced and negotiated joint custody, her father transformed from a secondary, disengaged parent to the primary caregiver. He stepped up to cook, clean, manage daily routines, and even taught Saxbe how to drive, eventually becoming a patient and steady presence in her life. This transformation illustrates that earlier withdrawal was not due to lack of love or care but inexperience and a lack of confidence in his parenting abilities.
Becky Kennedy reinforces that many fathers feel awkward and incompetent with caregiving tasks—sometimes holding their baby for the first time or not knowing how to diaper or swaddle—leading to avoidance. Rather than a lack of desire to engage, fathers’ uncertainty and discomfort with unfamiliar parenting responsibilities push them to withdraw to familiar environments, such as the workplace, where they feel more competent. This withdrawal is reinforced by social norms around masculinity that often discourage men from seeking support or admitting vulnerability.
Kennedy emphasizes the importance of interpreting a partner’s withdrawal with generosity. The natural, least generous interpretation when a partner pulls away is to assume indifference or lack of commitment, such as believing, “They don’t care about the child or the workload.” Instead, Kennedy suggests considering whether the withdrawal is rooted in uncertainty and a feeling of incompetence. If so, the issue is workable and presents an opportunity for collaboration rather than conflict.
Focusing on a compassionate interpretation fosters better communication. Kennedy proposes addressing the challenge by acknowledging the learning curve both parents face: “This is new for both of us. I know it can be hard to know where to start with diapering or with learning ...
Reframing Paternal Withdrawal: Fathers' Disengagement From Incompetence and Uncertainty, Not Lack of Care
Darby Saxbe shares the story of how her father transformed from a secondary parent to a steady, patient, and primary caregiver during her teenage years. The transition brought her father a deep sense of meaning and purpose, especially after a difficult divorce. In a letter, he revealed that parenthood kept him moving forward even during the hardest times, expressing that it ultimately became the most meaningful part of his life. Becky Kennedy echoes this, observing that for many fathers, active parenting becomes the source of their greatest fulfillment.
Saxbe describes meaningful family routines with her father, such as Monday movie nights at the video rental store, Friday evenings at Friendly’s for sundaes, and Sunday trips to church, where he sang in the choir. These shared rituals created lasting memories and fostered a sense of connection, demonstrating how daily acts of caring build deep father-child bonds and impart lasting significance to family roles.
Saxbe points to emerging research, including large studies from the UK Biobank repository, which holds tens of thousands of mid- and late-life brain scans. These studies reveal that individuals with more children tend to have “younger-looking” brains: their neurological age, as measured by scan markers, is lower than their chronological age. This effect holds true for both mothers and fathers, indicating the benefits are not specific to female biology or pregnancy.
Saxbe suggests that the neuroprotective effects of parenting may stem from the demanding social integration and family investment required by parenthood. The relational intensity and the ongoing engagement with family members may help preserve cognitive function and promote healthier aging, showing that both men and women benefit from the active, socially engaged roles that parenting requires.
Becky Kennedy highlights that when fathers—or any parents—start something new, awkwardness is inevitable. Our brains often interpret this awkwardness as a sign of failure or incompetence, prompting us to withdraw. However, reframing awkwardness as a natural aspect of novelty allows parents to continue learning and growing, rather than retreating to comfort zones. Kennedy stresses that every meaningful and worthwhile undertaking feels hard at first and that this discomfort signals growth, not ...
Valuing Fatherhood: Celebrating Fathers' Impact on Families and Future Generations, With Parenthood's Neuroprotective Benefits
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