{"id":99555,"date":"2023-04-16T06:45:00","date_gmt":"2023-04-16T10:45:00","guid":{"rendered":"https:\/\/www.shortform.com\/blog\/?p=99555"},"modified":"2023-04-21T10:46:50","modified_gmt":"2023-04-21T14:46:50","slug":"blood-sugar-and-heart-disease","status":"publish","type":"post","link":"https:\/\/www.shortform.com\/blog\/blood-sugar-and-heart-disease\/","title":{"rendered":"The Link Between Blood Sugar and Heart Disease"},"content":{"rendered":"\n<p>What is the link between high blood sugar and heart disease? Can frequent blood sugar spikes cause your heart to fail? <\/p>\n\n\n\n<p>High blood sugar increases your risk of developing heart disease\u2014among other health conditions. This is because it damages blood vessels by causing cholesterol to accumulate and can also damage the nerves that control the heart and blood vessels. <\/p>\n\n\n\n<p>Keep reading to learn how elevated blood sugar can lead to heart disease. <\/p>\n\n\n\n<!--more-->\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-heart-disease-and-blood-sugar\"><strong>Heart Disease&nbsp;and Blood Sugar<\/strong><\/h2>\n\n\n\n<p>How are blood sugar and heart disease related? Elevated glucose levels and frequent <a href=\"https:\/\/www.shortform.com\/blog\/glucose-spikes\/\">glucose spikes<\/a> can lead to heart disease in the long term. This is because glucose spikes contribute to cholesterol accumulation beneath the lining of our blood vessels, which sets off heart disease.\u00a0<\/p>\n\n\n\n<p>(Shortform note: <a href=\"https:\/\/www.niddk.nih.gov\/health-information\/diabetes\/overview\/preventing-problems\/heart-disease-stroke#:~:text=High%20blood%20glucose%20from%20diabetes,can%20lead%20to%20heart%20disease.&amp;text=People%20with%20diabetes%20tend%20to,age%20than%20people%20without%20diabetes\" target=\"_blank\" rel=\"noreferrer noopener\">Persistently high glucose levels can also damage the nerves that control the heart and blood vessels.<\/a> This nerve damage further contributes to heart disease and increases your chance of having a stroke. People with high glucose levels from diabetes are almost twice as likely to experience heart disease or stroke.)<\/p>\n\n\n\n<p>How do glucose spikes lead to cholesterol accumulation? The cells lining our blood vessels are highly susceptible to mitochondrial stress, which glucose spikes directly contribute to. When experiencing mitochondrial stress, the blood vessel lining\u2019s cells go from even to irregular in shape, making it easy for cholesterol to get caught in the grooves of the lining.&nbsp;<\/p>\n\n\n\n<p>(Shortform note: Research has increasingly focused on the <a href=\"https:\/\/academic.oup.com\/cardiovascres\/article\/95\/2\/173\/292010\" target=\"_blank\" rel=\"noreferrer noopener\">role of mitochondrial dysfunction in the development and progression of vascular diseases<\/a> (diseases relating to the body\u2019s vessels, especially blood vessels), particularly atherosclerosis, or the buildup of fat on the inner walls of arteries. High glucose levels exacerbate oxidative stress and inflammation, two conditions linked to atherosclerosis. There\u2019s ongoing research into potential therapeutic interventions targeting mitochondrial damage and dysfunction for the treatment of vascular diseases, including treatments that suppress <a href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphys.2022.1084604\/full\" target=\"_blank\" rel=\"noreferrer noopener\">mitochondrial production of free radicals<\/a> called reactive oxygen species.)<\/p>\n\n\n\n<p>Additionally, when our glucose levels make our insulin levels too high, our liver begins producing a small type of cholesterol called LDL pattern B that gets stuck more easily on the edges of blood vessels than other types of cholesterol. High levels of glucose, fructose, and insulin contribute to the oxidization of LDL pattern B, making it even more likely to stick under the lining of our blood vessels. Finally, we experience heart disease when enough cholesterol accumulates to start hindering our blood flow.&nbsp;<\/p>\n\n\n\n<p>(Shortform note: Cholesterol is a type of fat, and it must be connected to a protein to travel through the body. <a href=\"https:\/\/www.heartuk.org.uk\/cholesterol\/what-is-cholesterol#:~:text=Cholesterol%20is%20a%20type%20of%20fat%2C%20and%20fats%20can%27t,lipoprotein%27%20means%20fat%20plus%20protein\" target=\"_blank\" rel=\"noreferrer noopener\">LDL cholesterol is a type of lipoprotein<\/a>\u2014a particle made of fat and protein. Specifically, it\u2019s a low-density lipoprotein, meaning it contains more fat than protein. LDL cholesterol delivers fat to the cells as needed. In contrast, HDL cholesterol (or high-density lipoproteins) brings cholesterol to the liver, which eliminates the cholesterol from the body. Though research supports Inchausp\u00e9\u2019s idea that the prevalence of small, sticky LDL pattern B cholesterol is connected to external factors such as glucose levels, <a href=\"https:\/\/mainheartclinic.com\/2011\/05\/cholesterol-particle-size\/#:~:text=Individuals%20with%20pattern%20A%20are,and%20dense%20LDL%20cholesterol%20particles.\" target=\"_blank\" rel=\"noreferrer noopener\">there\u2019s also a genetic component<\/a> to the size of our LDL cholesterol.)<\/p>\n","protected":false},"excerpt":{"rendered":"<p>What is the link between high blood sugar and heart disease? Can frequent blood sugar spikes cause your heart to fail? High blood sugar increases your risk of developing heart disease\u2014among other health conditions. This is because it damages blood vessels by causing cholesterol to accumulate and can also damage the nerves that control the heart and blood vessels. Keep reading to learn how elevated blood sugar can lead to heart disease.<\/p>\n","protected":false},"author":7,"featured_media":68685,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[16,160],"tags":[984],"class_list":["post-99555","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-health","category-science","tag-glucose-revolution","","tg-column-two"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v24.3 (Yoast SEO v24.3) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>The Link Between Blood Sugar and Heart Disease - Shortform Books<\/title>\n<meta name=\"description\" content=\"High blood sugar increases your risk of heart disease. This is because it causes cholesterol to accumulate under the lining of blood vessels.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.shortform.com\/blog\/blood-sugar-and-heart-disease\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"The Link Between Blood Sugar and Heart Disease\" \/>\n<meta property=\"og:description\" content=\"High blood sugar increases your risk of heart disease. This is because it causes cholesterol to accumulate under the lining of blood vessels.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.shortform.com\/blog\/blood-sugar-and-heart-disease\/\" \/>\n<meta property=\"og:site_name\" content=\"Shortform Books\" \/>\n<meta property=\"article:published_time\" content=\"2023-04-16T10:45:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-04-21T14:46:50+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/s3.amazonaws.com\/wordpress.shortform.com\/blog\/wp-content\/uploads\/2022\/06\/heart-model.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1347\" \/>\n\t<meta property=\"og:image:height\" content=\"730\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Darya Sinusoid\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Darya Sinusoid\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/www.shortform.com\/blog\/blood-sugar-and-heart-disease\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.shortform.com\/blog\/blood-sugar-and-heart-disease\/\"},\"author\":{\"name\":\"Darya Sinusoid\",\"@id\":\"https:\/\/www.shortform.com\/blog\/#\/schema\/person\/0421cce75bc249b11e2517b3a91f9c46\"},\"headline\":\"The Link Between Blood Sugar and Heart Disease\",\"datePublished\":\"2023-04-16T10:45:00+00:00\",\"dateModified\":\"2023-04-21T14:46:50+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www.shortform.com\/blog\/blood-sugar-and-heart-disease\/\"},\"wordCount\":529,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/www.shortform.com\/blog\/#organization\"},\"image\":{\"@id\":\"https:\/\/www.shortform.com\/blog\/blood-sugar-and-heart-disease\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.shortform.com\/blog\/wp-content\/uploads\/2022\/06\/heart-model.jpg\",\"keywords\":[\"Glucose Revolution\"],\"articleSection\":[\"Health\",\"Science\"],\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/www.shortform.com\/blog\/blood-sugar-and-heart-disease\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.shortform.com\/blog\/blood-sugar-and-heart-disease\/\",\"url\":\"https:\/\/www.shortform.com\/blog\/blood-sugar-and-heart-disease\/\",\"name\":\"The Link Between Blood Sugar and Heart Disease - Shortform Books\",\"isPartOf\":{\"@id\":\"https:\/\/www.shortform.com\/blog\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/www.shortform.com\/blog\/blood-sugar-and-heart-disease\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/www.shortform.com\/blog\/blood-sugar-and-heart-disease\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.shortform.com\/blog\/wp-content\/uploads\/2022\/06\/heart-model.jpg\",\"datePublished\":\"2023-04-16T10:45:00+00:00\",\"dateModified\":\"2023-04-21T14:46:50+00:00\",\"description\":\"High blood sugar increases your risk of heart disease. 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