{"id":67708,"date":"2022-06-04T09:48:00","date_gmt":"2022-06-04T13:48:00","guid":{"rendered":"https:\/\/www.shortform.com\/blog\/?p=67708"},"modified":"2022-06-16T11:28:06","modified_gmt":"2022-06-16T15:28:06","slug":"david-sinclair-sirtuins","status":"publish","type":"post","link":"https:\/\/www.shortform.com\/blog\/david-sinclair-sirtuins\/","title":{"rendered":"David Sinclair: How Sirtuins Combat Aging"},"content":{"rendered":"\n

What are sirtuins? What function do sirtuins serve in the body? How can sirtuins help reverse the effects of aging?<\/p>\n\n\n\n

According to biologist David Sinclair, sirtuins\u2014enzymes that regulate the epigenome\u2014are the key to reversing aging. He believes he can reverse many of the effects of aging by bolstering our sirtuins because they\u2019re involved in everything from repairing DNA to suppressing inflammation\u2014all of which they accomplish by activating or deactivating certain genes in response to certain stressors. <\/p>\n\n\n\n

Here’s how sirtuins can help combat aging.<\/p>\n\n\n\n\n\n\n\n

Clearing Epigenetic \u201cNoise\u201d With Sirtuins<\/strong><\/h2>\n\n\n\n

According to David Sinclair, sirtuins have to move away from their usual functions in order to repair DNA damage. <\/strong>As we age and start suffering from more and more problems, this leads to two issues: First, the sirtuins aren\u2019t able to get back to their positions before they have to rush out to repair more damage. Second, sometimes they don\u2019t return to the correct positions. These two things lead to epigenetic chaos\u2014genes that should be active are deactivated, and vice versa. <\/p>\n\n\n\n

Therefore, manipulating sirtuins to work more effectively\u2014which scientists have done in mice with drugs like resveratrol\u2014helps combat the effects of aging and extends life. The next step, Sinclair says, is to find drugs that cause the same effects in humans. <\/p>\n\n\n\n

(Shortform note: Sirtuins are a relatively new area of study, and while initial research results look promising, there isn\u2019t yet much evidence that we can effectively manipulate them in humans or that we\u2019d get the desired results by doing so. A scientific review from 2020 summed up the results<\/a> of many different studies on sirtuins in organisms ranging from yeasts to primates. In short, it says that sirtuins are \u201cpromising targets\u201d for therapies to treat everything from age-related diseases to cancer, but there are still few (if any) studies using human subjects.) <\/p>\n\n\n\n

What Causes Epigenetic \u201cNoise\u201d?<\/strong>

According to the National Institutes of Health<\/a> (NIH), the epigenome responds to various stressors such as pollutants, diseases, and an unhealthy diet by undergoing small changes<\/a> to enable the body to endure those stressors. In fact, the NIH says those changes may be necessary for us to survive. However, they can also lead to illnesses if too many genes are being activated and deactivated incorrectly. 

To give a simple example: If you get a small cut, your epigenome would activate the genes you need to heal\u2014genes that produce clotting agents and genes that make your skin cells divide rapidly to heal the wound, among others. This is perfectly normal and usually doesn\u2019t cause any harm. The problems arise when the epigenome doesn\u2019t correctly reset itself; for instance, if those skin cells don\u2019t stop <\/em>dividing once the wound is closed, you could develop skin cancer. <\/td><\/tr><\/tbody><\/table><\/figure>\n","protected":false},"excerpt":{"rendered":"

What are sirtuins? What function do sirtuins serve in the body? How can sirtuins help reverse the effects of aging? According to biologist David Sinclair, sirtuins\u2014enzymes that regulate the epigenome\u2014are the key to reversing aging. He believes he can reverse many of the effects of aging by bolstering our sirtuins because they\u2019re involved in everything from repairing DNA to suppressing inflammation\u2014all of which they accomplish by activating or deactivating certain genes in response to certain stressors.  Here’s how sirtuins can help combat aging.<\/p>\n","protected":false},"author":7,"featured_media":15540,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[16,160],"tags":[632],"class_list":["post-67708","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-health","category-science","tag-lifespan","","tg-column-two"],"yoast_head":"\nDavid Sinclair: How Sirtuins Combat Aging - Shortform Books<\/title>\n<meta name=\"description\" content=\"According to biologist and geneticist David Sinclair, sirtuins are the key to reversing DNA damage. 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