{"id":1663,"date":"2019-09-26T19:58:35","date_gmt":"2019-09-26T23:58:35","guid":{"rendered":"https:\/\/www.shortform.com\/blog\/?p=1663"},"modified":"2022-03-08T10:06:41","modified_gmt":"2022-03-08T14:06:41","slug":"emil-jay-freireich","status":"publish","type":"post","link":"https:\/\/www.shortform.com\/blog\/emil-jay-freireich\/","title":{"rendered":"The Greatest Lesson From Chemotherapy Pioneer Jay Freireich"},"content":{"rendered":"\n<p>Who is Jay Freireich? And what can this doctor and researcher teach us about making use of so-called disadvantages?<br><\/p>\n\n\n\n<p>Emil \u201cJay\u201d Freireich is a doctor who pioneered chemotherapy as a treatment for childhood leukemia. <\/p>\n\n\n\n<p>However, he may never have persevered in the face of criticism and threats of being fired if he hadn\u2019t had such a <a href=\"https:\/\/www.shortform.com\/blog\/traumatic-childhood\/\">traumatic childhood<\/a>. We&#8217;ll cover how trauma can be an advantage and what you can learn from Jay Freireich\u2019s success.<\/p>\n\n\n\n<!--more-->\n\n\n\n<h2 class=\"wp-block-heading\">Jay Freireich\u2019s Childhood Trauma<\/h2>\n\n\n\n<p>Emil Freireich\u2019s parents, Hungarian immigrants, lost everything in the stock market crash of 1929. Shortly after, Freireich\u2019s father died, likely by suicide. Freireich\u2019s mother worked in a sweatshop eighteen hours every day to support her family until she remarried, at which point she fired the Irish maid Jay Freireich considered his real mother.<br><\/p>\n\n\n\n<p>When he was nine years old, a respectable doctor removed Jay Freireich\u2019s tonsils, and Freireich, having never had a man in his life that he looked up to, decided to become a doctor when he grew up. Another Hungarian immigrant gave Jay Freireich\u2019s mother $25 so he could go to college.<br><\/p>\n\n\n\n<p>As a child, he had conquered fear over and over again. <strong>Traumatic experiences trained him to be courageous in his career and overcome consensus opinion and risk.<\/strong><br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Emil Jay Freireich\u2019s Unorthodox Leukemia Treatment<\/h2>\n\n\n\n<p>While working at the National Cancer Institute (NCI), Jay Freireich developed two treatment strategies that horrified his colleagues and ended up being the keys to saving thousands of children\u2019s lives.<br><\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Jay Freireich&#8217;s First Treatment Strategy: Blood Transfusions<\/h3>\n\n\n\n<p>The ultimate goal of Jay Freireich\u2019s team was to cure leukemia, but kids with leukemia tend to bleed everywhere, both internally and externally. Young patients were bleeding to death before doctors could treat their leukemia. Freireich held the radical belief that cancer destroyed his patients\u2019 ability to make platelets. This, he said, was why their blood wouldn\u2019t clot.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Roadblock #1: Because Jay Freireich\u2019s platelet theory was unorthodox, the Institute blood bank wouldn\u2019t give him blood, and he had to recruit blood donors himself.<\/li><li>Roadblock #2: The conventional tools for transfusing blood were made of steel, rubber, and glass. But platelets stick to these surfaces. Jay Freireich decided to try the new silicon needles and plastic bags.<\/li><li>Roadblock #3: Transfusing using the new technology was risky. If done incorrectly, it could result in heart failure. Consequently, Jay Freireich\u2019s boss threatened to fire him if he kept transfusing platelets. Freireich ignored him.<\/li><\/ul>\n\n\n\n<p>The bleeding in Freireich\u2019s patients stopped. The team could now keep them alive long enough to treat their leukemia.<br><\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Jay Freireich&#8217;s Second Treatment Strategy: Drug Cocktails<\/h3>\n\n\n\n<p>At the time, doctors used one of three cell-killing drugs, in limited doses, to treat leukemia. Jay Freireich wanted to use all three at once, plus another derived from the periwinkle plant. All four drugs attacked the cancer cells differently, but doctors still considered combining them extremely dangerous. Freireich\u2019s attitude was, \u201cWhy not? They\u2019re going to die anyway.\u201d<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Roadblock #1: Because combining drugs was unheard of, and the periwinkle drug was a brand-new discovery, Jay Freireich and his colleague Frei had to experiment to hit on the right dosage amounts and timing. Some kids became paralyzed in the experimentation process, and two children died.<\/li><li>Roadblock #2: The NCI advisory board refused to approve the treatment, and Freireich and Frei had to wear down their boss to get approval.<\/li><li>Roadblock #3: Children started to recover, but then the cancer would come back. Jay Freireich decided to administer chemotherapy every month for a year, even when the children were in complete remission. This was dangerous (and highly controversial)&#8211;the drugs wiped out patients\u2019 immune systems, leaving them vulnerable to infections and disease.<\/li><\/ul>\n\n\n\n<p>Everyone thought Jay Freireich was insane, but he didn\u2019t care. <strong>His traumatic childhood had been much worse than the criticism of his peers.<\/strong> Today, the standard leukemia treatment is a modified version of Freireich\u2019s strategy and the cure rate is over 90%.<br><\/p>\n\n\n\n<p>Why was Jay Freireich so successful? As a child, he had conquered fear over and over again. Traumatic experiences taught him courage. The lesson? Use your disadvantages to your advantage.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Who is Jay Freireich? And what can this doctor and researcher teach us about making use of so-called disadvantages? Emil \u201cJay\u201d Freireich is a doctor who pioneered chemotherapy as a treatment for childhood leukemia. However, he may never have persevered in the face of criticism and threats of being fired if he hadn\u2019t had such a traumatic childhood. We&#8217;ll cover how trauma can be an advantage and what you can learn from Jay Freireich\u2019s success.<\/p>\n","protected":false},"author":4,"featured_media":1609,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[29,42,33],"tags":[47],"class_list":["post-1663","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-career","category-motivation","category-people","tag-david-and-goliath","","tg-column-two"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v24.3 (Yoast SEO v24.3) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>The Greatest Lesson From Chemotherapy Pioneer Jay Freireich - Shortform Books<\/title>\n<meta name=\"description\" content=\"Emil \u201cJay\u201d Freireich is a doctor who pioneered chemotherapy as a treatment for childhood leukemia. 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