{"id":15170,"date":"2020-09-25T23:22:00","date_gmt":"2020-09-26T03:22:00","guid":{"rendered":"https:\/\/www.shortform.com\/blog\/?p=15170"},"modified":"2020-10-12T12:14:21","modified_gmt":"2020-10-12T16:14:21","slug":"what-is-brain-on-fire-about","status":"publish","type":"post","link":"https:\/\/www.shortform.com\/blog\/what-is-brain-on-fire-about\/","title":{"rendered":"What Is Brain on Fire About? Rare Disease + Resilience"},"content":{"rendered":"\n

What is Brain on Fire <\/em>about? How did Susannah Cahalan live through her rare disease diagnosis?<\/p>\n\n\n\n

Brain on Fire<\/em> is a medical mystery about what suddenly changes a woman into someone unrecognizable. What is Brain on Fire<\/em> about? Resilience while fighting for a diagnosis and fighting a rare disease.<\/p>\n\n\n\n

Read more about the story of Susannah Cahalan and what Brain on Fire<\/em> is about. <\/p>\n\n\n\n\n\n\n\n

What Is Brain on Fire About?<\/h2>\n\n\n\n

So what is Brain on Fire<\/em> about? At 24 years old, Susannah Cahalan is an ambitious, dedicated reporter for the New York<\/em> Post<\/em>. She\u2019s admired by her colleagues and respected by her editors. Like most 24-year-olds, she thinks nothing can go wrong with her vibrant, happy life. Then, she becomes inexplicably sick and suffers from inexplicable behavior.<\/p>\n\n\n\n

Ineffectual Diagnoses<\/strong><\/h3>\n\n\n\n

Bailey conducts a routine neurological exam and declares everything is normal. He prescribes an MRI, which comes back normal. Bailey suggests Susannah has a virus, possibly mono.<\/strong> She\u2019s relieved to have a diagnosis.<\/strong><\/p>\n\n\n\n

Susannah returns to work. When she pitches two more stories and they\u2019re both rejected, she blames her poor performance on mono and takes another day off. Her doctor calls to tell her she doesn\u2019t have mono after all. Not long after, Susannah has her first seizure.<\/strong><\/p>\n\n\n\n

In the hospital, Susannah has more scary episodes and incorrect diagnoses. Finally, the doctors conclude that she has anti-NMDA-receptor encephalitis. Part of the question “what is Brain on Fire<\/em> about?” works to answer this question. <\/p>\n\n\n\n

A Diagnosis at Last<\/h3>\n\n\n\n

Susannah has been through a lot already and has a long road ahead, but finally has a diagnosis of anti-NMDA-receptor encephalitis. Everything we do, from lifting a glass to reading a book, results from a chemical signal triggering specific brain cells to fire or not. If a cell can\u2019t receive a signal, it can\u2019t initiate or inhibit behavior.<\/p>\n\n\n\n

Cells receive signals through receptors<\/em>. NMDA receptors excite cells that participate in learning, memory, higher functions, and personality. In 2007, Dr. Dalmau<\/a> identified a new disease that would come to be called anti-NMDA-receptor encephalitis. This condition is caused when antibodies disable NMDA receptors. Experiments indicate that a 40 percent loss of NMDA receptors results in psychosis. A 70 percent loss results in catatonia. An absence of any working NMDA receptors results in death.<\/p>\n\n\n\n

Susannah makes significant progress over the next few months, but her pills make her sleepy and slow, and sometimes she refuses to take them. In her own mind, she\u2019s uncertain about herself, but she always describes herself as nearly 100 percent back.<\/p>\n\n\n\n

Experts are called in to assess her progress. Susannah dreads the assessment, as the experts may contradict her assertion that she\u2019s fine. In fact, her fears turn out to be correct; the assessments reveal a divide between Susannah\u2019s internal world and the world around her.<\/strong><\/p>\n\n\n\n

She presents as severely impaired on tests of concentration, basic cognitive functioning, and working memory<\/a>, yet her performance on verbal functioning, abstract reasoning, and analytical thinking<\/a> reveal a different story. On those tests, Susannah places in the high to superior percentile. Dr. Bertisch, the psychologist who administers the test, concludes that Susannah\u2019s interior world does not match up with the way she presents externally. <\/p>\n\n\n\n

Susannah herself is aware of this divide. Social situations are especially difficult because she\u2019s aware of how strange she appears to the people around her. Susannah often feels that her true self<\/a> is trying to connect with the world outside but can\u2019t break past her body. <\/strong><\/p>\n\n\n\n

Susannah\u2019s old self finally reawakens when she\u2019s in the hospital for another round of treatments. She begins reading again. She begins keeping a diary to understand what\u2019s happened to her and helps her answer the question “What is Brain on Fire <\/em>about?”<\/p>\n\n\n\n

Susannah\u2019s father encourages her to draw upon her memory to create a timeline of events. As she tries to remember, she can recall only numbness, sleepiness, and three seizures. She remembers nothing from her time in the hospital.<\/strong><\/p>\n\n\n\n

So what is Brain on Fire<\/em> about? Susannah Cahalan’s book is about the journey to understand what was making her sick and reconstructing what happened to her after.<\/p>\n","protected":false},"excerpt":{"rendered":"

What is Brain on Fire about? How did Susannah Cahalan live through her rare disease diagnosis? Brain on Fire is a medical mystery about what suddenly changes a woman into someone unrecognizable. What is Brain on Fire about? Resilience while fighting for a diagnosis and fighting a rare disease. Read more about the story of Susannah Cahalan and what Brain on Fire is about.<\/p>\n","protected":false},"author":6,"featured_media":15320,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[40,16],"tags":[130],"class_list":["post-15170","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-books","category-health","tag-brain-on-fire","","tg-column-two"],"yoast_head":"\nWhat Is Brain on Fire About? Rare Disease + Resilience - Shortform Books<\/title>\n<meta name=\"description\" content=\"What is Brain on Fire about? 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