{"id":15114,"date":"2020-09-21T13:03:00","date_gmt":"2020-09-21T17:03:00","guid":{"rendered":"https:\/\/www.shortform.com\/blog\/?p=15114"},"modified":"2020-10-01T14:01:26","modified_gmt":"2020-10-01T18:01:26","slug":"souhel-najjar","status":"publish","type":"post","link":"https:\/\/www.shortform.com\/blog\/souhel-najjar\/","title":{"rendered":"Souhel Najjar: A Doctor Solving Medical Mysteries"},"content":{"rendered":"\n<p>Who is Dr. Souhel Najjar in<em> Brain on Fire<\/em>? How did he finally get Susannah her diagnosis?<\/p>\n\n\n\n<p>Souhel Najjar is a doctor with a reputation for solving medical mysteries. Susannah&#8217;s neurologist reached out to him before quitting her team.<\/p>\n\n\n\n<p>Read more about Dr. Souhel Najjar and how he handled Susannah&#8217;s case differently.<\/p>\n\n\n\n<!--more-->\n\n\n\n<h2 class=\"wp-block-heading\">A Difficult Case<\/h2>\n\n\n\n<p>Susannah\u2019s bloodwork and autoimmune tests come back negative. Her MRIs and CT scans are clean. Forced by this evidence to rule out most of the diagnoses they had in mind, <strong>Susannah\u2019s doctors begin to wonder whether they\u2019ll actually be able to figure out what\u2019s wrong with her.&nbsp;<\/strong><\/p>\n\n\n\n<p>Dr. Siegel informs Susannah\u2019s mom that Susannah\u2019s spinal tap shows an elevated number of white blood cells. This is usually a sign of infection or inflammation and indicates that Susannah\u2019s illness is physiological rather than emotional in nature.<\/p>\n\n\n\n<p>Under normal conditions, our immune system creates antibodies to combat infections from foreign invaders like viruses or bacteria. On rare occasions, the immune system manufactures antibodies that attack cells or tissues in a person\u2019s own body. When this happens, the person develops an <a href=\"https:\/\/www.shortform.com\/blog\/what-causes-autoimmune-disease-diet\/\">autoimmune disease<\/a> like lupus, <a href=\"https:\/\/www.shortform.com\/blog\/what-causes-multiple-sclerosis-risk-factors\/\">multiple sclerosis<\/a>, or the type of brain inflammation that Susannah suffered from.<\/p>\n\n\n\n<p>Dr. Siegel, the physician on whom Susannah\u2019s mom has pinned her hopes, quits Susannah\u2019s team. Susannah\u2019s mom is devastated. She now believes that Dr. Russo is their only hope\u2014until Russo brings up the name of a Dr. Souhel Najjar, the doctor to call when nothing makes sense. Both Russo and Dr. Najjar order a second spinal tap for Susannah.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Dr. Souhel Najjar Offers Guidance<\/h3>\n\n\n\n<p>Unbeknownst to Susannah\u2019s family, Siegel asked Najjar to join Susannah\u2019s team. Dr. Najjar has a track record of solving a number of mystery cases, and Siegel has confessed that he\u2019s stumped by Susannah\u2019s case. Based on Siegel\u2019s expert summary, Dr. Najjar suggests that Susannah might have viral encephalitis. Without seeing her, he prescribes an antiviral drug and recommends testing Susanah for viral encephalitis, caused by a herpes virus. <strong>Again, all the tests come back negative.<\/strong>&nbsp;<\/p>\n\n\n\n<p>Najjar next suggests that Susannah\u2019s condition might be an autoimmune response. He immediately puts Susannah on IVIG treatment, a protocol he used successfully on another patient. On April 2, a nurse arrives to give Susannah the first of five IVIG infusions. Hallucinating that the nurse is responsible for her illness, Susannah punches her in the chest.<\/p>\n\n\n\n<p>IVIG infusions contain healthy antibodies from thousands of blood donors. Each infusion costs more than $20,000.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Dr. Souhel Najjar Arrives<\/h3>\n\n\n\n<p>The mysterious Dr. Souhel Najjar finally shows up, to the excitement of Susannah\u2019s family. Explaining that <strong>in order to see the future, it\u2019s necessary to look backward<\/strong>, he asks Susannah\u2019s parents for a full medical history. He particularly notes symptoms the other doctors hadn\u2019t explored: her bedbug phobia, numbness and tingling in her hands, her faster heart rate. He addresses Susannah directly, as if he\u2019s speaking with a friend rather than a patient.<\/p>\n\n\n\n<p>His bedside manner is personal and heartfelt. When he was a boy, he did badly in school until one teacher recognized his potential. <strong>As a result, he has committed himself to never giving up on anyone.<\/strong><\/p>\n\n\n\n<p>But then the results of Susannah\u2019s second spinal tap come in. Her white blood cell count has gone from 20 to 80, indicating that her brain is probably inflamed. Dr. Russo changes the diagnosis from psychosis to inflammation from an unknown cause.<\/p>\n\n\n\n<p>The doctors start looking for a source of infection in Susannah\u2019s brain.&nbsp;<\/p>\n\n\n\n<p><strong>Dr. Souhel Najjar has a flash of insight: what if Susannah\u2019s inflammation is the result of an autoimmune reaction? What if her own immune system is attacking her brain? <\/strong>He recalls a paper written by a <a href=\"https:\/\/www.shortform.com\/blog\/dr-dalmau-brain-on-fire\/\">Dr. Dalmau<\/a> at the University of Pennsylvania, describing four young women stricken by a rare autoimmune disease. Could Susannah have the same condition?<\/p>\n\n\n\n<p>\u201cHer brain is on fire,\u201d he announces to Susannah\u2019s parents. Then he turns to her and says, \u201cI will do everything I can for you.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Who is Dr. Souhel Najjar in Brain on Fire? How did he finally get Susannah her diagnosis? Souhel Najjar is a doctor with a reputation for solving medical mysteries. Susannah&#8217;s neurologist reached out to him before quitting her team. Read more about Dr. Souhel Najjar and how he handled Susannah&#8217;s case differently.<\/p>\n","protected":false},"author":6,"featured_media":15301,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[16,33,9],"tags":[130],"class_list":["post-15114","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-health","category-people","category-psychology","tag-brain-on-fire","","tg-column-two"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v24.3 (Yoast SEO v24.3) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Souhel Najjar: A Doctor Solving Medical Mysteries - Shortform Books<\/title>\n<meta name=\"description\" content=\"Dr. Souhel Najjar was brought onto Susannah&#039;s medical team when everyone was stumped. He was able to finally diagnose her. Here&#039;s how.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.shortform.com\/blog\/souhel-najjar\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Souhel Najjar: A Doctor Solving Medical Mysteries\" \/>\n<meta property=\"og:description\" content=\"Dr. Souhel Najjar was brought onto Susannah&#039;s medical team when everyone was stumped. He was able to finally diagnose her. Here&#039;s how.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.shortform.com\/blog\/souhel-najjar\/\" \/>\n<meta property=\"og:site_name\" content=\"Shortform Books\" \/>\n<meta property=\"article:published_time\" content=\"2020-09-21T17:03:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2020-10-01T18:01:26+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/s3.amazonaws.com\/wordpress.shortform.com\/blog\/wp-content\/uploads\/2020\/09\/brain-on-fire-najjar-scaled.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"2560\" \/>\n\t<meta property=\"og:image:height\" content=\"1440\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Rina Shah\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Rina Shah\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/www.shortform.com\/blog\/souhel-najjar\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.shortform.com\/blog\/souhel-najjar\/\"},\"author\":{\"name\":\"Rina Shah\",\"@id\":\"https:\/\/www.shortform.com\/blog\/#\/schema\/person\/d07435826f13a8f422d5d333dceac287\"},\"headline\":\"Souhel Najjar: A Doctor Solving Medical Mysteries\",\"datePublished\":\"2020-09-21T17:03:00+00:00\",\"dateModified\":\"2020-10-01T18:01:26+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www.shortform.com\/blog\/souhel-najjar\/\"},\"wordCount\":696,\"commentCount\":1,\"publisher\":{\"@id\":\"https:\/\/www.shortform.com\/blog\/#organization\"},\"image\":{\"@id\":\"https:\/\/www.shortform.com\/blog\/souhel-najjar\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.shortform.com\/blog\/wp-content\/uploads\/2020\/09\/brain-on-fire-najjar-scaled.jpg\",\"keywords\":[\"Brain on Fire\"],\"articleSection\":[\"Health\",\"People\",\"Psychology\"],\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/www.shortform.com\/blog\/souhel-najjar\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.shortform.com\/blog\/souhel-najjar\/\",\"url\":\"https:\/\/www.shortform.com\/blog\/souhel-najjar\/\",\"name\":\"Souhel Najjar: A Doctor Solving Medical Mysteries - Shortform Books\",\"isPartOf\":{\"@id\":\"https:\/\/www.shortform.com\/blog\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/www.shortform.com\/blog\/souhel-najjar\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/www.shortform.com\/blog\/souhel-najjar\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.shortform.com\/blog\/wp-content\/uploads\/2020\/09\/brain-on-fire-najjar-scaled.jpg\",\"datePublished\":\"2020-09-21T17:03:00+00:00\",\"dateModified\":\"2020-10-01T18:01:26+00:00\",\"description\":\"Dr. Souhel Najjar was brought onto Susannah's medical team when everyone was stumped. 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