{"id":116531,"date":"2023-10-29T11:25:00","date_gmt":"2023-10-29T15:25:00","guid":{"rendered":"https:\/\/www.shortform.com\/blog\/?p=116531"},"modified":"2023-11-02T16:24:48","modified_gmt":"2023-11-02T20:24:48","slug":"biology-of-aging","status":"publish","type":"post","link":"https:\/\/www.shortform.com\/blog\/biology-of-aging\/","title":{"rendered":"The Biology of Aging: 5 Structures That Cause Damage"},"content":{"rendered":"\n

What’s the biology of aging? What types of structures harm your body as they deteriorate?<\/p>\n\n\n\n

A process key to aging is the deterioration of structures and signals within and between your cells. In Ageless<\/em>, Andrew Steels explains that these structures and signals play a role in many diseases and dysfunctions associated with aging.<\/p>\n\n\n\n

We’ll take a look at five structures and signals that do extensive damage as they deteriorate.<\/p>\n\n\n\n\n\n\n\n

1. Telomeres Shorten<\/h2>\n\n\n\n

To explain the biology of aging, we’ll first discuss how telomeres shorten. Telomeres are<\/a> protective structures at the end of your chromosomes that prevent them from becoming frayed or tangled<\/strong>, but they get shorter as the cell divides repeatedly. Steele explains that telomeres help ensure your DNA replicates correctly when a cell divides. However, the machinery that completes this process can\u2019t copy the full length of the chromosome, so the very end of the telomere is lost each time. Shortened telomeres appear in patients with diabetes, heart disease, reduced immunity, and cancer, and are associated with a higher risk of death.\u00a0<\/p>\n\n\n\n

The potential fix<\/strong>: Steele explains that an enzyme called telomerase might help. It\u2019s disabled in most adult cells, and adding an extra copy of the telomerase gene helps a cell live on. But, he cautions that this might not be wise, since 90% of cancers turn telomerase back on (enabling cells to divide continuously). Other ideas include using gene therapy to lengthen telomeres directly, or employing telomerase activators (like a chemical called TA-65) to reactivate telomerase genes temporarily to reap the benefits of the enzyme without significantly increasing cancer risk.<\/p>\n\n\n\n

Do Telomeres Live Up to the Hype?<\/strong>

In The Telomere Effect<\/em><\/a>, biochemist Elizabeth Blackburn compares telomeres to aglets<\/a>, the protective tips that keep shoelaces from fraying as they sustain wear and tear. In addition to ensuring all the critical information in your DNA gets copied properly, your telomeres help your body enforce the Hayflick limit<\/a>: the number of times\u2014usually 40 or 60\u2014that each of your cells can divide. Once a cell divides enough times, the telomere becomes too short for the chromosome it protects to be replicated again, so the cell stops dividing. 

When the link between a person\u2019s age and the length of their telomeres was first discovered, some scientists (and many longevity enthusiasts) thought lengthening telomeres was the key to curing aging<\/a>. After all, helping cells extend their telomeres<\/a> offers a way around the Hayflick limit. This seemed even more promising because Blackburn discovered that in healthy cells, telomeres rebuild themselves with telomerase, which lengthens the strand of DNA before it gets copied. But it turns out that striking a balance is tricky: If telomerase is underactive, chromosomes shorten and cells die. But if telomerase is overactive, cancer risk is elevated. While Steele suggests using gene therapy or compounds like TA-65 to lengthen telomeres, some experts consider the entire link between telomeres and longevity debunked. Recent research suggests that short telomeres and long telomeres<\/a> both lead to problems.

While short telomeres predispose people to immune system problems and degenerative diseases, long telomeres seem to increase a person\u2019s risk of developing cancer and other disorders. <\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n

2. Mitochondria Become Less Efficient<\/h2>\n\n\n\n

Mitochondria, which generate energy within your cells, also deteriorate over time<\/strong> and cause aging in your brain, heart, and muscles. They become less plentiful and less efficient at producing energy in several ways. First, mitochondria contain their own chromosomes, and their DNA sustains damage and accumulates mutations. Second, when the process of generating power goes wrong, mitochondria produce reactive molecules called free radicals, which damage your proteins and DNA. And finally, dysfunctional mitochondria accumulate as your body gets less efficient at recycling them (and eventually play a role in Parkinson\u2019s and Alzheimer\u2019s). <\/p>\n\n\n\n

The potential fix<\/strong>: Steele writes that antioxidants could protect mitochondria against free radical damage. Scientists could also develop drugs that enhance mitophagy, your body\u2019s process for removing damaged and ineffective mitochondria. It might also be possible to reduce the effect of DNA mutations if scientists can insert a backup copy of mitochondrial genes, or use mitolytic drugs (which are currently hypothetical) to kill cells that no longer have functional mitochondria. <\/p>\n\n\n\n

Powering Up Mitochondria<\/strong>

Scientists characterize mitochondria as the \u201cpowerhouses<\/a>\u201d of your cells. In The Vital Question<\/em><\/a>, biochemist Nick Lane explains that our mitochondria descend<\/a> from a hybrid of two single-celled organisms. That\u2019s why mitochondria have their own DNA, which is subject to damage and mutations<\/a> as you age. Scientists are working on ideas for keeping mitochondria healthy, but current approaches are experimental, and some experts are skeptical about the ideas Steele cites. For instance, he mentions the idea of inserting backup copies of mitochondrial DNA into the nucleus, an idea some experts think is so ambitious, it\u2019s not practical<\/a> to try. 

Similarly, some experts say the \u201cfree radical theory of aging\u201d\u2014which Steele invokes when he suggests using antioxidants to protect mitochondria\u2014has fallen out of favor. But others are returning to it after the discovery in 2023 of a compound that inhibits free radical production<\/a> in mitochondria. While evidence suggests that taking large doses of antioxidants doesn\u2019t stave off aging, some experts contend that this new compound can block free radicals without inhibiting mitochondria\u2019s energy production. This advance\u2014along with treatments that stimulate mitophagy<\/a>\u2014could bring us closer to keeping mitochondria young and healthy.<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n

3. Your DNA Gets Damaged and Mutates<\/h2>\n\n\n\n

DNA damage (and the mutations that result from this damage) is another form of age-related deterioration\u2014and one of the most difficult to fix, according to Steele<\/strong>. Each of your cells contains DNA, the genetic code for building and maintaining your body. This code is constantly damaged by toxins, carcinogens, and radiation\u2014but most of all by the process of metabolizing food into energy. Your body can often repair the damage, but sometimes the repair process malfunctions and causes a mutation: a change to the instructions in your DNA. Mutations change how cells behave and can cause cancer or other consequences.<\/p>\n\n\n\n

The potential fix<\/strong>: Steele writes that researchers could improve our natural DNA repair machinery, perhaps by adding or altering genes. They could also work to counter the effects of common DNA mutations, target the genes that enable mutated cells to make thousands of copies of themselves, or experiment with using stem cells to replace mutated cells. <\/p>\n\n\n\n

Therapy for Your DNA<\/strong>

Your body is made of trillions of cells<\/a>, and each contains your DNA. Many scientists agree with Steele that DNA\u2019s susceptibility to damage and mutation is one of the most challenging<\/a> problems of aging. But why do cells accumulate damage and mutations, despite having mechanisms that protect against these problems? Experts say that evolution made these safeguards just \u201cgood enough.\u201d If a cell repaired all the damage, the energy costs would outweigh the benefits of the repairs. 

Fortunately, scientists think that we can step in to repair some of the damage that our DNA accrues, like the gene therapy ideas that Steele cites. In The Gene<\/em><\/a>, Siddhartha Mukherjee asserts that gene therapy<\/a>\u2014which uses genetic engineering<\/a> to modify genes that are damaged or cause disease\u2014could be the future of medicine. However, Mukherjee notes that progress has been slow, in part due to ethical concerns: Many scientists think that while it\u2019s acceptable to use the primary tool of genetic engineering, CRISPR<\/a>, to cure a disease in an individual, the tool shouldn\u2019t be used to make changes to the genome<\/a>, because those changes, along with any unforeseen consequences, can be passed onto the next generation. <\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n

4. Epigenetics Get Less Effective at Controlling Your Genetic Code<\/h2>\n\n\n\n

Age-related deterioration also affects \u201cepigenetics,\u201d the chemical code that annotates your DNA and changes how genes are expressed. Steele writes that epigenetic annotations become less effective as you age<\/strong>\u2014to the extent that epigenetic marks called DNA methylation predict your \u201cepigenetic age.\u201d If you have an epigenetic age lower than your chronological age, then you\u2019re biologically younger, with better health and a lower risk of death. (Shortform note: DNA methylation decreases with age, so gene expression becomes less controlled as we get older.) <\/p>\n\n\n\n

The potential fix<\/strong>: Steele explains that when scientists create iPSCs, restoring the ability of adult cells to turn into any cell type, the epigenetic age of these cells resets to zero. Because reprogramming your body\u2019s cells into iPSCs would cause them to stop functioning as you need them to, scientists could reprogram cells temporarily, develop drugs that mimic some of the effects of reprogramming, or change chemical groups called \u201cepigenetic marks\u201d on your DNA.<\/p>\n\n\n\n

Backing Up the Instructions<\/strong>

Because all of your cells carry your entire DNA, they need instructions to tell them what kind of cell they should become and what function they need to carry out. The epigenome provides this set of instructions<\/a> via chemical groups called epigenetic marks<\/em>. According to David Sinclair\u2019s \u201cInformation Theory of Aging<\/a>,\u201d detailed in Lifespan<\/em><\/a>, aging occurs due to the loss of these instructions<\/a>. Sinclair has conducted research which he contends proves we can reverse aging<\/a> by equipping cells with a backup copy of their original epigenetic instructions. 

Additionally, Steele explains that we might treat epigenetic decline with two methods detailed earlier in the guide. First, epigenetic reprogramming\u2014which Steele cites as a potential therapy for senescent cells\u2014makes a cell\u2019s epigenetic profile more youthful. This means that it could restore the flagging function of the epigenome. Second, generating iPSCs, detailed in the section on stem cells, rewinds mature cells\u2019 epigenetic age<\/a> to zero, which demonstrates the power of epigenetics to affect aging. <\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n

5. Communication Between Cells Goes Down<\/h2>\n\n\n\n

Finally, some contributors to aging don\u2019t happen inside your cells, but instead involve the deterioration of the signals in the cells\u2019 <\/strong>environment<\/em><\/strong>. Steele explains that signals constantly travel around your body: inflammatory signals, nutrient-sensing signals (which help you process nutrients), and signaling factors in blood. All of these signals become more dysfunctional<\/strong> as you age. <\/p>\n\n\n\n

The potential fix<\/strong>: Steele explains that old blood cells can be rejuvenated by young blood. But because human trials of plasma transfusions from young donors haven\u2019t yielded results, scientists are investigating alternatives such as plasmapheresis (a procedure that removes harmful substances from blood) and drugs that modulate the signaling factors in the blood.<\/p>\n\n\n\n

Sending Mixed Signals<\/strong>

Other experts agree with Steele that many of the signals that travel between cells and systems become less functional with age. Experts say blood is a promising anti-aging target<\/a> because it circulates around your body, carrying oxygen, nutrients, and compounds involved in the aging process. It also carries many of the signals that Steele cites as deteriorating as we age: Chemicals<\/a> from your white blood cells are responsible for inflammation<\/a>. That includes chronic inflammation, which occurs as levels of inflammatory substances become elevated<\/a> and is considered a key part of aging<\/a> by some scientists.

Steele also mentions the idea of rejuvenating old blood with plasmapheresis, drug treatments, or transfusions of young blood\u2014a method that hasn\u2019t yielded results. But that hasn\u2019t stopped people from trying: Venture capitalist Bryan Johnson has made headlines<\/a> for taking more than 100 supplements<\/a> a day, completing strenuous workouts, eating a strict diet that leaves him hungry most of the time<\/a>, doing extensive medical testing\u2014and undergoing blood-plasma transfusions<\/a> from his teenage son. He stopped the transfusions after finding that they didn\u2019t make a difference, and the FDA has warned that such infusions aren\u2019t safe or effective<\/a>. <\/td><\/tr><\/tbody><\/table><\/figure>\n","protected":false},"excerpt":{"rendered":"

What’s the biology of aging? What types of structures harm your body as they deteriorate? A process key to aging is the deterioration of structures and signals within and between your cells. In Ageless, Andrew Steels explains that these structures and signals play a role in many diseases and dysfunctions associated with aging. We’ll take a look at five structures and signals that do extensive damage as they deteriorate.<\/p>\n","protected":false},"author":14,"featured_media":104883,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[16,160],"tags":[1311],"class_list":["post-116531","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-health","category-science","tag-ageless","","tg-column-two"],"yoast_head":"\nThe Biology of Aging: 5 Structures That Cause Damage - Shortform Books<\/title>\n<meta name=\"description\" content=\"When we get older, our bodies' signals and structures start to wear down. 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