{"id":11555,"date":"2020-07-24T12:30:00","date_gmt":"2020-07-24T16:30:00","guid":{"rendered":"https:\/\/www.shortform.com\/blog\/?p=11555"},"modified":"2022-04-01T15:53:34","modified_gmt":"2022-04-01T19:53:34","slug":"hela-cells-hpv-18-cancer","status":"publish","type":"post","link":"https:\/\/www.shortform.com\/blog\/hela-cells-hpv-18-cancer\/","title":{"rendered":"HeLa Cells, HPV, and the Future of Human Evolution"},"content":{"rendered":"\n<p>How have HeLa cells been used to understand viruses? What is the connection between HeLa cells, HPV, and <a href=\"https:\/\/www.shortform.com\/blog\/cancer-progression\/\">cancer progression<\/a>? Did Henrietta suffer from HPV-18?<\/p>\n\n\n\n<p>HPV-18 is a particularly severe form of HPV. After examining original tissue from Henrietta Lacks, HPV of this strain was found. Studies of HeLa cells and HPV can explain the fatal progression of Henrietta Lacks&#8217;s cancer.<\/p>\n\n\n\n<p>Read more about HeLa cells, HPV, and theories about immortality using HeLa cells. <\/p>\n\n\n\n<!--more-->\n\n\n\n<p>While Henrietta\u2019s surviving family was suffering, her cells were still thriving\u2014and helping to study and treat viruses like Human Papilloma Virus (HPV) and Human Immunodeficiency Virus (HIV).<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Henrietta Lacks: HPV Found in Original Tissue<\/h2>\n\n\n\n<p>About a year before the appearance of Gold\u2019s book, a german virologist discovered an especially virulent strain of HPV: HPV-18. Once he discovered that the HeLa cells in his lab tested positive for the strain, he requested a sample from Henrietta\u2019s original tissue to rule out the possibility his HeLa cells were contaminated. <strong>He found that Henrietta had been infected with <\/strong><strong><em>multiple copies<\/em><\/strong><strong> of HPV-18<\/strong>.&nbsp;<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">HeLa Cells, HPV, and Cancer<\/h2>\n\n\n\n<p>As HPV research progressed throughout the 80s\u2014the German virologist would eventually be awarded the Nobel Prize for developing an HPV vaccine\u2014scientists were able to determine precisely how Henrietta\u2019s cancer started. HPV infects cells by inserting its DNA into its host and causing the host to turn cancerous; <strong>in Henrietta\u2019s case, the HPV DNA in her cervical cells turned off a tumor suppressor gene<\/strong>. HeLa cells and HPV have a clear connection.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Immortality and Other Theories<\/h2>\n\n\n\n<p>Although scientists were able to discover the root cause of Henrietta\u2019s cancer, they were at a loss to explain why her cells flourished so incredibly in culture. Henrietta\u2019s Clover relatives, however, had their own theories: Divine punishment for leaving Clover or original sin, or malevolent spirits. <strong>Henrietta\u2019s cousin Sadie even wondered whether Henrietta\u2019s insides had been colonized by something from outer space<\/strong>.<br><\/p>\n\n\n\n<p>Ironically, some scientists at the time were asking a related question: Were HeLa cells even still human? The scientists argued that HeLa cells, because they\u2019d been reproducing (through cell division) and evolving separately from the human species for so long, had become <em>their own species<\/em>. (Most scientists dismissed this argument, with one observing that, if Henrietta were still alive and able to provide a sample, her DNA would match HeLa\u2019s.)<br><\/p>\n\n\n\n<p>Studying HeLa cells, HPV is just one small negative of the tissue.  HeLa cells also contributed to renewed speculation about the possibility of everlasting life.&nbsp; Whereas healthy human cells inevitably died in culture after dividing about fifty times, cancerous cells\u2014as exemplified by HeLa\u2014divided indefinitely. One indication that healthy cells are nearing their end is the progressive shortening of their chromosomes\u2019 \u201ctelomeres\u201d\u2014strings of DNA at the end of each chromosome. In the early 90s, a Yale researcher studying HeLa cells discovered that HeLa produces a particular enzyme that prevents the telomeres from shortening, thereby enabling the cell to continue dividing.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>How have HeLa cells been used to understand viruses? What is the connection between HeLa cells, HPV, and cancer progression? Did Henrietta suffer from HPV-18? HPV-18 is a particularly severe form of HPV. After examining original tissue from Henrietta Lacks, HPV of this strain was found. Studies of HeLa cells and HPV can explain the fatal progression of Henrietta Lacks&#8217;s cancer. Read more about HeLa cells, HPV, and theories about immortality using HeLa cells.<\/p>\n","protected":false},"author":6,"featured_media":11755,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[16,39],"tags":[111],"class_list":["post-11555","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-health","category-history","tag-the-immortal-life-of-henrietta-lacks","","tg-column-two"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v24.3 (Yoast SEO v24.3) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>HeLa Cells, HPV, and the Future of Human Evolution - Shortform Books<\/title>\n<meta name=\"description\" content=\"In studying HeLa cells, HPV was found in Henrietta Lacks&#039;s original tissue. The strain found, HPV-18, is severe and may explain her quick cancer death.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.shortform.com\/blog\/hela-cells-hpv-18-cancer\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"HeLa Cells, HPV, and the Future of Human Evolution\" \/>\n<meta property=\"og:description\" content=\"In studying HeLa cells, HPV was found in Henrietta Lacks&#039;s original tissue. The strain found, HPV-18, is severe and may explain her quick cancer death.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.shortform.com\/blog\/hela-cells-hpv-18-cancer\/\" \/>\n<meta property=\"og:site_name\" content=\"Shortform Books\" \/>\n<meta property=\"article:published_time\" content=\"2020-07-24T16:30:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2022-04-01T19:53:34+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/s3.amazonaws.com\/wordpress.shortform.com\/blog\/wp-content\/uploads\/2020\/07\/the-immortal-life-of-henrietta-lacks-hela-hpv.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1184\" \/>\n\t<meta property=\"og:image:height\" content=\"536\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Rina Shah\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Rina Shah\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/www.shortform.com\/blog\/hela-cells-hpv-18-cancer\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.shortform.com\/blog\/hela-cells-hpv-18-cancer\/\"},\"author\":{\"name\":\"Rina Shah\",\"@id\":\"https:\/\/www.shortform.com\/blog\/#\/schema\/person\/d07435826f13a8f422d5d333dceac287\"},\"headline\":\"HeLa Cells, HPV, and the Future of Human Evolution\",\"datePublished\":\"2020-07-24T16:30:00+00:00\",\"dateModified\":\"2022-04-01T19:53:34+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www.shortform.com\/blog\/hela-cells-hpv-18-cancer\/\"},\"wordCount\":513,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/www.shortform.com\/blog\/#organization\"},\"image\":{\"@id\":\"https:\/\/www.shortform.com\/blog\/hela-cells-hpv-18-cancer\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.shortform.com\/blog\/wp-content\/uploads\/2020\/07\/the-immortal-life-of-henrietta-lacks-hela-hpv.jpg\",\"keywords\":[\"The Immortal Life of Henrietta Lacks\"],\"articleSection\":[\"Health\",\"History\"],\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/www.shortform.com\/blog\/hela-cells-hpv-18-cancer\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.shortform.com\/blog\/hela-cells-hpv-18-cancer\/\",\"url\":\"https:\/\/www.shortform.com\/blog\/hela-cells-hpv-18-cancer\/\",\"name\":\"HeLa Cells, HPV, and the Future of Human Evolution - Shortform Books\",\"isPartOf\":{\"@id\":\"https:\/\/www.shortform.com\/blog\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/www.shortform.com\/blog\/hela-cells-hpv-18-cancer\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/www.shortform.com\/blog\/hela-cells-hpv-18-cancer\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.shortform.com\/blog\/wp-content\/uploads\/2020\/07\/the-immortal-life-of-henrietta-lacks-hela-hpv.jpg\",\"datePublished\":\"2020-07-24T16:30:00+00:00\",\"dateModified\":\"2022-04-01T19:53:34+00:00\",\"description\":\"In studying HeLa cells, HPV was found in Henrietta Lacks's original tissue. 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