{"id":10594,"date":"2020-07-15T18:55:00","date_gmt":"2020-07-15T22:55:00","guid":{"rendered":"https:\/\/www.shortform.com\/blog\/?p=10594"},"modified":"2020-07-17T15:00:51","modified_gmt":"2020-07-17T19:00:51","slug":"adenosine-and-sleep","status":"publish","type":"post","link":"https:\/\/www.shortform.com\/blog\/adenosine-and-sleep\/","title":{"rendered":"Adenosine and Sleep: The Science of Being Tired"},"content":{"rendered":"\n<p>What is adenosine and what do adenosine and sleep have to do with each other?<\/p>\n\n\n\n<p>Adenosine and sleep are closely related. Adenosine is a chemical that signals that you&#8217;re tired and causes you to want to go to sleep. This is called &#8220;sleep pressure&#8221;\u2014or just feeling tired. Adenosine is what actually causes that sleepy feeling. <\/p>\n\n\n\n<!--more-->\n\n\n\n<h2 class=\"wp-block-heading\">Adenosine and Sleep: <strong>How Sleep Rhythm Works<\/strong><\/h2>\n\n\n\n<p>Sleep is regulated by two mechanisms:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>The <strong>circadian rhythm<\/strong>, regulated by <strong>melatonin<\/strong> (produced by the suprachiasmatic nucleus in the brain). Think of this as a natural \u201cwake drive,\u201d making you stay awake during the day and waning during night.<ul><li>The circadian rhythm responds to light and darkness to calibrate itself. It\u2019s naturally 14 hours and 15 minutes long on average.<\/li><\/ul><\/li><li><strong>Adenosine<\/strong> and sleep fatigue is a signal and causes \u201csleep pressure.\u201d This rises consistently through the day without sleep, making you feel more tired. Sleeping depletes adenosine, and you wake up with a lower level.<\/li><\/ul>\n\n\n\n<p>These two mechanisms interact as shown in this graph:<\/p>\n\n\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/lh5.googleusercontent.com\/aCHmmtC_jtE27b02DrDiY3ti1z-BPJLBfJTxGlswfstX8gyfz-ZqUi4KI54wyOj1uxDPAGUEmDYSzoEdyWZ-oi32iHBSPh_trhQl7arQIUpsUrjZ-kV8AlE9clH-uHA3jWdK6BEA\" alt=\"\"\/><\/figure>\n\n\n\n<p>Notice that sleep naturally happens when the difference between curves is greatest &#8211; you feel the greatest sleep pressure from the adenosine sleep chemical, and the least \u201cwake drive\u201d from your circadian rhythm.<\/p>\n\n\n\n<p>This explains an odd phenomenon between adenosine and sleep: if you\u2019ve ever had to pull an all-nighter, you might have noticed yourself getting a second wind in the morning, oddly feeling more awake at 8AM than at 3AM. This happens because the circadian rhythm \u201cwake drive\u201d is starting up again, and reduces the adenosine-circadian gap.<br><\/p>\n\n\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/lh6.googleusercontent.com\/Hxk3qHsYA4Dje4w2HDckRFNKyDu3QHU21Xki6kIrPZFtuBPhTmmOnHxnavujtPoTZ-QSElDhsBxWb5x-c87gRnjLNuCaXmeMFckdzrQOQjxR7vYis2FKa3m1cosBJ-XeoDJHtg97\" alt=\"\"\/><\/figure>\n\n\n\n<p>Circadian rhythms vary from person to person, depending on when they naturally wake up and have maximum energy. The idea of \u201cmorning people\u201d and \u201cnight owls\u201d is real, and when adenosine and sleep kick in depends on <a href=\"https:\/\/www.shortform.com\/blog\/your-genius\/\">who you are<\/a>. <\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Whether you\u2019re a morning or night person strongly depends on your genetics.&nbsp;<\/li><li>Why would humans evolve with this variation? Evolutionarily, having a mixture of morning people and night owls allows a population to reduce its vulnerability in nighttime to a shorter period of time.&nbsp;<ul><li>Example: As morning people sleep earlier (say at 10PM), night owls can keep up the watch. Then as night owls get tired (say around 4AM), the morning people are starting to wake.<\/li><\/ul><\/li><li>But in modern times, the night owls are heavily punished, since early work times force night owls to sleep and wake up earlier than they would naturally prefer. This reduces performance in the mornings. Furthermore, by the time night owls peak in the afternoon, the work day has already ended.<\/li><\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>How You Disrupt Your Sleep Rhythm<\/strong><\/h3>\n\n\n\n<p>Now that you understand how <a href=\"https:\/\/www.shortform.com\/blog\/sleep-rhythm-why-we-sleep\/\">sleep rhythm<\/a> works and know the answer to the question, &#8220;What is adenosine?&#8221;, you can better understand common disruptions to sleep.<\/p>\n\n\n\n<p><strong>Caffeine blocks adenosine receptors, thus reducing how much you feel the \u201csleep pressure.\u201d<\/strong> If you ever drink coffee and then feel a crash later, this comes from caffeine wearing off while the adenosine sleep chemical keeps increasing throughout the day.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Caffeine has a half-life of 5-7 hours, depending on genetics for the cytochrome P450 enzyme in your liver. Some people metabolize caffeine more quickly than others.<\/li><li>Be careful when drinking decaf, as it apparently contains 15-30% of the caffeine in regular coffee &#8211; it\u2019s nowhere near zero caffeine.<\/li><\/ul>\n\n\n\n<p><strong>Jetlag disrupts your circadian rhythm.&nbsp;<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Jetlag is usually worse when you fly eastbound because adjusting your schedule requires falling asleep when the body wants to be awake. This is more difficult than staying awake when your body wants to sleep.<\/li><li>Since the circadian rhythm is slightly longer than a day, lengthening it is easier than shortening it.<\/li><\/ul>\n\n\n\n<p><strong>How do you know if you have a sleep deficit? Here are a few signs:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>You don\u2019t wake up naturally at the time you set your alarm &#8211; this means your body wants more sleep.<\/li><li>When you read, you often lose track and need to read a sentence twice.&nbsp;<\/li><li>You feel drowsy just a few hours after waking.<\/li><li>You need coffee to feel functional.<\/li><\/ul>\n\n\n\n<p>Luckily, <em>Why We Sleep<\/em> also discusses how to improve sleep, and responding to things like adenosine sleep functions and how to improve your sleeping habits and reduce your sleep deficit.<\/p>\n\n\n\n<p>Now you know the answer to the question, &#8220;What is adenosine?&#8221;, and you&#8217;ve learned about the relationship between adenosine and sleep. So when you&#8217;re tired, you know that adenosine and sleep are at work\u2014and it&#8217;s time to head to bed. <\/p>\n","protected":false},"excerpt":{"rendered":"<p>What is adenosine and what do adenosine and sleep have to do with each other? Adenosine and sleep are closely related. Adenosine is a chemical that signals that you&#8217;re tired and causes you to want to go to sleep. This is called &#8220;sleep pressure&#8221;\u2014or just feeling tired. Adenosine is what actually causes that sleepy feeling.<\/p>\n","protected":false},"author":5,"featured_media":10651,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[16],"tags":[98],"class_list":["post-10594","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-health","tag-why-we-sleep","","tg-column-two"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v24.3 (Yoast SEO v24.3) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Adenosine and Sleep: The Science of Being Tired - Shortform Books<\/title>\n<meta name=\"description\" content=\"Adenosine and sleep: How are they related? 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Adenosine is the chemical that makes you feel like you&#039;re so tired you can&#039;t hold your head up\u2014here&#039;s why.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.shortform.com\/blog\/adenosine-and-sleep\/\" \/>\n<meta property=\"og:site_name\" content=\"Shortform Books\" \/>\n<meta property=\"article:published_time\" content=\"2020-07-15T22:55:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2020-07-17T19:00:51+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/s3.amazonaws.com\/wordpress.shortform.com\/blog\/wp-content\/uploads\/2020\/07\/adenosine-why-we-sleep-scaled.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"2560\" \/>\n\t<meta property=\"og:image:height\" content=\"1707\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Carrie Cabral\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Carrie Cabral\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"4 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/www.shortform.com\/blog\/adenosine-and-sleep\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.shortform.com\/blog\/adenosine-and-sleep\/\"},\"author\":{\"name\":\"Carrie Cabral\",\"@id\":\"https:\/\/www.shortform.com\/blog\/#\/schema\/person\/2ababb7c63a94ff5d2190f71dc417d56\"},\"headline\":\"Adenosine and Sleep: The Science of Being Tired\",\"datePublished\":\"2020-07-15T22:55:00+00:00\",\"dateModified\":\"2020-07-17T19:00:51+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www.shortform.com\/blog\/adenosine-and-sleep\/\"},\"wordCount\":752,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/www.shortform.com\/blog\/#organization\"},\"image\":{\"@id\":\"https:\/\/www.shortform.com\/blog\/adenosine-and-sleep\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.shortform.com\/blog\/wp-content\/uploads\/2020\/07\/adenosine-why-we-sleep-scaled.jpg\",\"keywords\":[\"Why We Sleep\"],\"articleSection\":[\"Health\"],\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/www.shortform.com\/blog\/adenosine-and-sleep\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.shortform.com\/blog\/adenosine-and-sleep\/\",\"url\":\"https:\/\/www.shortform.com\/blog\/adenosine-and-sleep\/\",\"name\":\"Adenosine and Sleep: The Science of Being Tired - Shortform Books\",\"isPartOf\":{\"@id\":\"https:\/\/www.shortform.com\/blog\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/www.shortform.com\/blog\/adenosine-and-sleep\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/www.shortform.com\/blog\/adenosine-and-sleep\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.shortform.com\/blog\/wp-content\/uploads\/2020\/07\/adenosine-why-we-sleep-scaled.jpg\",\"datePublished\":\"2020-07-15T22:55:00+00:00\",\"dateModified\":\"2020-07-17T19:00:51+00:00\",\"description\":\"Adenosine and sleep: How are they related? 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