{"id":104831,"date":"2023-06-11T09:27:00","date_gmt":"2023-06-11T13:27:00","guid":{"rendered":"https:\/\/www.shortform.com\/blog\/?p=104831"},"modified":"2023-06-12T09:56:47","modified_gmt":"2023-06-12T13:56:47","slug":"us-drug-shortages","status":"publish","type":"post","link":"https:\/\/www.shortform.com\/blog\/us-drug-shortages\/","title":{"rendered":"The US Drug Shortage: Causes and Potential Solutions"},"content":{"rendered":"\n<p>What\u2019s behind the shortage of hundreds of drugs in the US? What can be done to fix the problem?<\/p>\n\n\n\n<p>The US drug shortage is so severe that physicians at large cancer centers have virtually no supply of chemotherapy drugs left. Experts attribute much of the drug shortage problem to an ailing generic drug manufacturing market, which accounts for 90% of all domestic prescriptions.<\/p>\n\n\n\n<p>Below we&#8217;ll take a look at what&#8217;s causing the US drug shortage and if anything can be done to remedy it.<\/p>\n\n\n\n<!--more-->\n\n\n\n<h2 class=\"wp-block-heading\">Causes and Effects of the US Drug Shortage<\/h2>\n\n\n\n<p>The US began 2023 with <a href=\"https:\/\/apnews.com\/article\/drug-shortages-adderall-ozempic-855632a04a17c2bf75b6a89e4c08ef79\" target=\"_blank\" rel=\"noreferrer noopener\">301 active drug shortages<\/a>\u201449% higher than in 2018 and a record five-year high. Physicians in 35 states, including those at large cancer centers and teaching hospitals, say they have little or no supply of chemotherapy drugs. The US drug shortage is so severe that life-saving treatments for patients with lung, breast, bladder, and ovarian cancers are being delayed. Doctors call the shortage a public health emergency.\u00a0<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-background\"><strong>Background<\/strong><\/h3>\n\n\n\n<p>When doctors are aware that a drug shortage is on the horizon, they do what they can to mitigate the problem.<strong> Some prepare for shortages by <\/strong><a href=\"https:\/\/www.nbcnews.com\/health\/cancer\/cancer-drug-shortages-14-medicines-now-short-supply-fda-says-rcna86106\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>rationing drug doses<\/strong><\/a>. Once the drug is gone, however, there\u2019s no dose left to round down.\u00a0Physicians also substitute scarce drugs with alternatives when possible. <\/p>\n\n\n\n<p><strong>Sometimes doctors have no warning of a drug shortage\u2014suppliers simply stop filling their orders<\/strong>.&nbsp;<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-drug-shortage-causes\"><strong>Drug Shortage Causes<\/strong><\/h3>\n\n\n\n<p>Experts attribute the dearth of drugs in the US to a host of factors, most notably, a <a href=\"https:\/\/www.nytimes.com\/2023\/05\/17\/health\/drug-shortages-cancer.htmlhttps:\/\/www.nytimes.com\/2023\/05\/17\/health\/drug-shortages-cancer.html\" target=\"_blank\" rel=\"noreferrer noopener\">struggling generic drug market<\/a>. The association representing generic drug makers recently warned members of Congress that a number of US generic manufacturers are at risk of bankruptcy and closing up shop. Troubles these drug makers confront include:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Narrow margins and narrowing profits<\/strong>. Although consumers have benefited from a 50% drop in generic drug prices over the last seven years, those lower costs mean slim margins for manufacturers, who <a href=\"https:\/\/www.bloomberg.com\/news\/articles\/2023-05-10\/drug-shortages-quality-woes-get-secret-white-house-attention?sref=mIZ1p2Gz\" target=\"_blank\" rel=\"noreferrer noopener\">cut expenses<\/a> where possible to compensate. <\/li><li><a href=\"https:\/\/www.nytimes.com\/2023\/05\/17\/health\/drug-shortages-cancer.html\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>Shutdowns<\/strong><\/a>. When the Federal Drug Administration identifies quality control problems, it requires manufacturers to temporarily cease production of those drugs, which is costly for drug makers.<\/li><li><a href=\"https:\/\/www.bloomberg.com\/news\/articles\/2023-05-10\/drug-shortages-quality-woes-get-secret-white-house-attention?sref=mIZ1p2Gz\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>Financially induced production limits<\/strong><\/a>. Because manufacturers can\u2019t afford to produce excess quantities of drugs, they don\u2019t. As a result, they can\u2019t respond to sudden surges in demand.<\/li><li><a href=\"https:\/\/www.nytimes.com\/2023\/05\/17\/health\/drug-shortages-cancer.html\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>Generic market consolidation competition<\/strong><\/a>. Just three buyers\u2014tied to the retail chains CVS, Walmart, and Walgreens\u2014comprise 90% of generic drug purchases. US generic drug manufacturers compete with companies in India (whose <a href=\"https:\/\/www.shortform.com\/blog\/the-cost-of-labor\/\">labor costs<\/a> are lower) for contracts with these buyers. When they lose a contract for a drug they often stop producing it, which further diminishes their already-slim profits.\u00a0<\/li><\/ul>\n\n\n\n<p>Experts cite several additional reasons for ongoing drug shortages in the US, including:&nbsp;&nbsp;<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><a href=\"https:\/\/apnews.com\/article\/drug-shortages-adderall-ozempic-855632a04a17c2bf75b6a89e4c08ef79\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>Reliance on China and India<\/strong><\/a><strong> for drugs\u2019 raw ingredients<\/strong>, which countries restricted during the pandemic to protect their domestic supply.<\/li><li><a href=\"https:\/\/www.nytimes.com\/2023\/05\/17\/health\/drug-shortages-cancer.html\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>Skyrocketing demand<\/strong><\/a>, as recently seen with <a href=\"https:\/\/shortform.com\/app\/article\/how-a-weight-loss-drug-boom-is-upending-the-diet-industry-shortform-explainers-shortform\" target=\"_blank\" rel=\"noreferrer noopener\">weight-loss drugs<\/a>.<\/li><li><strong>Overprescribing of drugs<\/strong> like antibiotics.<\/li><li><a href=\"https:\/\/www.foxnews.com\/health\/new-report-suggests-panic-buying-of-medications-by-patients-and-providers-caused-drug-shortages\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>Panic buying<\/strong><\/a> in response to fears of drug shortages.<\/li><\/ul>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-drug-shortage-solutions\"><strong>Drug Shortage Solutions&nbsp;<\/strong><\/h3>\n\n\n\n<p>The drug shortage problem is severe enough that in 2021,<strong> the White House <\/strong><a href=\"https:\/\/www.bloomberg.com\/news\/articles\/2023-05-10\/drug-shortages-quality-woes-get-secret-white-house-attention?sref=mIZ1p2Gz\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>convened a team<\/strong><\/a><strong> of national security, economic, and health experts to identify strategies to bolster the supply chain<\/strong>. Though their work is ongoing, early solutions that they and others propose to address shortages include:\u00a0<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Offering tax breaks<\/strong> to ramp up US manufacturing of generic drugs and <a href=\"https:\/\/www.nytimes.com\/2023\/05\/17\/health\/drug-shortages-cancer.html\" target=\"_blank\" rel=\"noreferrer noopener\">incentivize increased transparency<\/a> around generic drug quality.\u00a0<\/li><li><strong>Developing tools to <\/strong><a href=\"https:\/\/www.bloomberg.com\/news\/articles\/2023-05-10\/drug-shortages-quality-woes-get-secret-white-house-attention?sref=mIZ1p2Gz\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>predict medication shortages<\/strong><\/a><strong> before they begin<\/strong>.<\/li><li>Creating quality scores for manufacturing facilities.<\/li><li>Ramping up unannounced FDA inspections.<\/li><li><strong>Launching an exchange to <\/strong><a href=\"https:\/\/www.nytimes.com\/2023\/05\/17\/health\/drug-shortages-cancer.html\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>triage drugs<\/strong><\/a><strong> where they\u2019re most needed<\/strong>.<\/li><li><a href=\"https:\/\/www.nytimes.com\/2023\/05\/17\/health\/drug-shortages-cancer.html\" target=\"_blank\" rel=\"noreferrer noopener\">Ramping up production of small-batch medicines<\/a> (called \u201ccompounding\u201d).<\/li><li><a href=\"https:\/\/www.nytimes.com\/2023\/05\/17\/health\/drug-shortages-cancer.html\" target=\"_blank\" rel=\"noreferrer noopener\">Expanding government contracts<\/a> with Civica, a nonprofit that sells generic drugs at slightly higher prices, to stabilize the generic drug market.\u00a0<\/li><\/ul>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-looking-ahead\"><strong>Looking Ahead<\/strong><\/h3>\n\n\n\n<p>Experts fear that if the shortage crisis continues, <a href=\"https:\/\/www.usatoday.com\/story\/news\/health\/2023\/05\/30\/cancer-drug-chemotherapy-shortage-solutions-explained\/70253377007\/\" target=\"_blank\" rel=\"noreferrer noopener\">every US hospital will feel the pain<\/a>. And Americans in desperate need of life-saving medications will simply have to wait and hope for the best.\u00a0<\/p>\n","protected":false},"excerpt":{"rendered":"<p>What\u2019s behind the shortage of hundreds of drugs in the US? What can be done to fix the problem? The US drug shortage is so severe that physicians at large cancer centers have virtually no supply of chemotherapy drugs left. Experts attribute much of the drug shortage problem to an ailing generic drug manufacturing market, which accounts for 90% of all domestic prescriptions. Below we&#8217;ll take a look at what&#8217;s causing the US drug shortage and if anything can be done to remedy it.<\/p>\n","protected":false},"author":8,"featured_media":104832,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[81,16],"tags":[727],"class_list":["post-104831","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-economics","category-health","tag-articles","","tg-column-two"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v24.3 (Yoast SEO v24.3) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>The US Drug Shortage: Causes and Potential Solutions - Shortform Books<\/title>\n<meta name=\"description\" content=\"The generic drug shortages in the US are increasing and becoming dangerous for patients. 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